Mutation in katG315 is, possibly, a good prognostic marker for treatment with second-line drugs in multi-drug resistant tuberculosis: A preliminary study.

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dc.contributor.authorAhmed, Mohanad M
dc.contributor.authorMohammed, Suhad H
dc.contributor.authorNasurallah, Hassan A A
dc.date.accessioned2015-03-13T11:29:39Z
dc.date.available2015-03-13T11:29:39Z
dc.date.issued2013-10
dc.description.abstractThe aim of this study was to explore baseline data, laboratory and molecular analyses to determine if any could serve as potential prognostic marker(s) for treatment response to second line tuberculosis regimens. Of a total number of 50 multi-drug resistant tuberculosis (MDR-TB) patients starting second-line drug MDR-TB treatment in Iraq, only 21 showed treatment adherence and thus, included in this study. Response to treatment was monitored for 11 months by sputum microscopy and culture. We explored baseline data, laboratory and molecular analyses to determine if any could serve as potential prognostic marker(s) for treatment response. Highly signifi cant association (P = 0.019) was detected between mutations in katG315 codon and good response to second-line anti-TB drugs. Spoligotyping and mycobacterial interspersed repetitive unit variable number tandem repeat confi rmed that katG315-mutatnt isolates were genotypically unrelated. The katG315 mutation is a potential prognostic marker for treatment response to second-line anti-tuberculosis drugs. One possible explanation of our results is that the katG315-mutants are sensitive to bacterial killing by “oxidative killing.”en_US
dc.identifier.citationAhmed Mohanad M, Mohammed Suhad H, Nasurallah Hassan A A. Mutation in katG315 is, possibly, a good prognostic marker for treatment with second-line drugs in multi-drug resistant tuberculosis: A preliminary study. Indian Journal of Medical Microbiology. 2013 Oct-Dec; 31(4): 395-400.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/156824
dc.language.isoenen_US
dc.source.urihttps://www.ijmm.org/article.asp?issn=0255-0857;year=2013;volume=31;issue=4;spage=395;epage=400;aulast=Ahmeden_US
dc.subjectKatG315en_US
dc.subjectmulti-drug resistanten_US
dc.subjectsecond-line drugsen_US
dc.subjecttuberculosisen_US
dc.titleMutation in katG315 is, possibly, a good prognostic marker for treatment with second-line drugs in multi-drug resistant tuberculosis: A preliminary study.en_US
dc.typeArticleen_US
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