Dyslipidemia and Superoxide Dismutase Activity in Children with Down Syndrome.

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dc.contributor.authorGoyal, P
dc.contributor.authorSingh, R
dc.contributor.authorYadav, A
dc.contributor.authorDutta, A K
dc.contributor.authorBhattacharjee, J
dc.date.accessioned2013-07-01T05:46:43Z
dc.date.available2013-07-01T05:46:43Z
dc.date.issued2010-09
dc.description.abstractIntroduction: Down Syndrome (trisomy 21) provides an interesting natural model to study atherosclerosis, since these individuals appear to be protected from plaque formation. Methodology: We assessed the lipid levels, and superoxide dismutase (SOD) activity in 32 clinically diagnosed children of Down syndrome and 34 children matched for age and sex as controls. Results: SOD activity was found to be significantly higher (p=0.004) in children with Down Syndrome (mean=313.7 IU/ml) than in controls (mean140.2 IU/ ml). Significantly higher levels of serum triglyceride (154.7 mg/dl) and VLDL (33.9 mg/dl) were observed in Down Syndrome as compared to healthy controls (119.6 mg/dl and 23.9 mg/dl respectively; p<0.05 for each). However, the two groups did not show any significant difference in levels of serum HDL-C, LDL-C. Conclusion: The raised antioxidant activity of SOD, because of over expression of genes situated non chromosome 21, probably offers some protection against the development of atherosclerosis despite the occurrence of dyslipidemia.en_US
dc.identifier.citationGoyal P, Singh R, Yadav A, Dutta A K, Bhattacharjee J. Dyslipidemia and Superoxide Dismutase Activity in Children with Down Syndrome. Journal of Nepal Paediatric Society. 2010 Sept-Dec; 30(3): 160-163.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/147086
dc.language.isoenen_US
dc.source.urihttps://www.nepjol.info/index.php/JNPS/article/view/3919/3327en_US
dc.subjectChromosome 21en_US
dc.subjectDown Syndromeen_US
dc.subjectTrisomy 21en_US
dc.subjectSuperoxide dismutaseen_US
dc.titleDyslipidemia and Superoxide Dismutase Activity in Children with Down Syndrome.en_US
dc.typeArticleen_US
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