Alpha-1 antitrypsin deficiency among Indian children with liver disorders.

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dc.contributor.authorKhanna, Rajeeven_US
dc.contributor.authorAlam, Seemaen_US
dc.contributor.authorSherwani, Ranaen_US
dc.contributor.authorArora, Shivalien_US
dc.contributor.authorArora, N Ken_US
dc.contributor.authorMalik, Ashrafen_US
dc.date.accessioned2006-07-16en_US
dc.date.accessioned2009-05-29T03:11:47Z
dc.date.available2006-07-16en_US
dc.date.available2009-05-29T03:11:47Z
dc.date.issued2006-07-16en_US
dc.description.abstractAIMS: To determine the frequency of alpha-1 antitrypsin (AAT) deficiency in children with chronic liver disease (CLD) and neonatal cholestasis syndrome (NCS). METHODS: All children with NCS (n=23) or CLD (n=35) attending the Pediatric Gastroenterology Clinic between November 2003 and July 2005 were screened for AAT deficiency using phenotyping through isoelectric focusing of plasma. RESULTS: Of the 58 children studied, 57 had normal PiMM phenotype. One child with CLD had the M1E type of normal variant. None of the patients had the abnormal phenotype PiZZ. CONCLUSION: AAT deficiency is infrequent among children with CLD and NCS in our region.en_US
dc.description.affiliationDepartment of Pediatrics, J.N. Medical College, AMU, Aligarh 202002, India.en_US
dc.identifier.citationKhanna R, Alam S, Sherwani R, Arora S, Arora NK, Malik A. Alpha-1 antitrypsin deficiency among Indian children with liver disorders. Indian Journal of Gastroenterology. 2006 Jul-Aug; 25(4): 191-3en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/65050
dc.language.isoengen_US
dc.source.urihttps://www.indianjgastro.comen_US
dc.subject.meshAlanine Transaminase --blooden_US
dc.subject.meshCeruloplasmin --analysisen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshCholestasis --complicationsen_US
dc.subject.meshHumansen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshLiver Diseases --complicationsen_US
dc.subject.meshPhenotypeen_US
dc.subject.meshProthrombin Timeen_US
dc.subject.meshalpha 1-Antitrypsin Deficiency --complicationsen_US
dc.titleAlpha-1 antitrypsin deficiency among Indian children with liver disorders.en_US
dc.typeJournal Articleen_US
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