Comparative evaluation of two indigenously developed tests for rapid detection of group-A streptococci directly from throat swabs.

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dc.contributor.authorGupta, Ren_US
dc.contributor.authorKalia, Aen_US
dc.contributor.authorRattan, Aen_US
dc.contributor.authorKumar, Ren_US
dc.contributor.authorGupta, S Ken_US
dc.date.accessioned1997-05-01en_US
dc.date.accessioned2009-05-27T08:45:02Z
dc.date.available1997-05-01en_US
dc.date.available2009-05-27T08:45:02Z
dc.date.issued1997-05-01en_US
dc.description.abstractThe efficacy of two indigenously developed rapid tests, latex agglutination and antibody capture assay (a colour immunochromatographic assay) to detect group A Streptococcus pyogenes (GAS) was evaluated in comparison with the traditional culture method ('Gold Standard') in both asymptomatic children (1500) and symptomatic patients (233). Throat swabs were taken in duplicate and rapid tests performed on one swab and culture on the other. Both latex agglutination and antibody capture assays showed a sensitivity of 100 per cent and specificity of > 98 per cent as compared to culture and isolation in symptomatic patients. However, among asymptomatic carriers sensitivity of 100 per cent and 87.5 per cent and specificity > 95 per cent were observed for latex agglutination and antibody capture assays respectively. Latex agglutination showed no false negative results and sensitivity was not affected by low beta-haemolytic counts in asymptomatic children. The rapid tests described here will help in the detection and thereby the management of GAS infection.en_US
dc.description.affiliationGamete Antigen Laboratory, National Institute of Immunology, New Delhi.en_US
dc.identifier.citationGupta R, Kalia A, Rattan A, Kumar R, Gupta SK. Comparative evaluation of two indigenously developed tests for rapid detection of group-A streptococci directly from throat swabs. Indian Journal of Medical Research. 1997 May; 105(): 200-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/25512
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAntibodies, Bacterial --analysisen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshLatex Fixation Tests --methodsen_US
dc.subject.meshMaleen_US
dc.subject.meshPharynx --microbiologyen_US
dc.subject.meshStreptococcal Infections --diagnosisen_US
dc.subject.meshStreptococcus pyogenes --isolation & purificationen_US
dc.titleComparative evaluation of two indigenously developed tests for rapid detection of group-A streptococci directly from throat swabs.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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