The Genetics of Primary Open Angle Glaucoma Interventions: Therapeutic Directions and Future Predictions

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dc.contributor.authorUmezurike, BCen_US
dc.contributor.authorAkhimien, MOen_US
dc.contributor.authorChukwuka, Cen_US
dc.contributor.authorEjike, Ten_US
dc.contributor.authorUgwulor, Len_US
dc.contributor.authorAjoku, Ben_US
dc.contributor.authorIjioma, SN.en_US
dc.date.accessioned2024-12-02T11:58:32Z
dc.date.available2024-12-02T11:58:32Z
dc.date.issued2024-08
dc.description.abstractThe “multifactorial chronic optic neuropathy” known as primary open angle glaucoma (POAG) is typified by a “progressive loss of retinal ganglion cells (RGC), structural damage to the retinal nerve fiber layer (RNFL) and optic nerve head (ONH), as well as abnormalities in the visual field.” High intraocular pressure (IOP), age, genetics, family history, race, etc. are the main risk factors. One of the pathological implications of POAG is “pressure-induced” ONH damage, which results in modifications to the expression of retinal genes. The ensuing fluid backup raises IOP, which damages optic nerve and results in POAG. Numerous susceptibility genes and environmental factors contribute to the “genetic heterogeneity” of POAG, according to genetic studies. “A set of twelve chromosomal loci, referred to as GLC1A through GLC1L, have been mapped for POAG. Three genes—myocilin (MYOC), optic neuropathy-inducing protein (Optineurin, OPTN)), and WD repeat domain 36 (WDR36)—have been identified as the GLC1A, GLC1E, and GLC1G”. A better understanding of the molecular genetic pathways and the pathological mechanisms involving the disease-causing genes, may help clarify the pathophysiology that leads to the disease and a targeted treatment. The role of genetics in POAG highlights the importance of genes in recent research advances, their future directions, applications, and therapy. The advent of modern genetic discoveries and future directions in vector engineering makes the cure for POAG possible. The paradigm shift in glaucoma treatment has moved from direct RGC and ONH therapy to targeting associated brain centers.en_US
dc.identifier.affiliationsDepartment of Optometry, Faculty of Allied Health Sciences, Gregory University, Uturu, Abia State, Nigeriaen_US
dc.identifier.affiliationsState Team Lead, African Field Epidemiology Network, AFENET/NSTOP, Gusau Field Office, Commissioners quarter, Gusau, Zamfara State, Nigeriaen_US
dc.identifier.affiliationsDepartment of Optometry, Faculty of Allied Health Sciences, Gregory University, Uturu, Abia State, Nigeriaen_US
dc.identifier.affiliationsDepartment of Optometry, Faculty of Allied Health Sciences, Gregory University, Uturu, Abia State, Nigeriaen_US
dc.identifier.affiliationsDepartment of Public Health, Faculty of Allied Health Sciences, Gregory University, Uturu, Abia State, Nigeriaen_US
dc.identifier.affiliationsDepartment of Public Health, Faculty of Allied Health Sciences, Gregory University, Uturu, Abia State, Nigeriaen_US
dc.identifier.affiliationsDepartment of Human Physiology, Micheal Okpara University of Agriculture, Umudike, Umuahia, Nigeria.en_US
dc.identifier.citationUmezurike BC, Akhimien MO, Chukwuka C, Ejike T, Ugwulor L, Ajoku B, Ijioma SN.. The Genetics of Primary Open Angle Glaucoma Interventions: Therapeutic Directions and Future Predictions. Ophthalmology Research: An International Journal. 2024 Aug; 19(5): 1-19en_US
dc.identifier.issn2321–7227
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/240604
dc.languageenen_US
dc.publisherMs. M. B. Mondalen_US
dc.relation.issuenumber5en_US
dc.relation.volume19en_US
dc.source.urihttps://doi.org/10.9734/or/2024/v19i5435en_US
dc.subjectPrimary open angle glaucomaen_US
dc.subjectglaucoma geneen_US
dc.subjectmutationen_US
dc.subjectgene locusen_US
dc.subjectgene therapyen_US
dc.subjectgenetic mappingen_US
dc.subjectmendelian inheritanceen_US
dc.subjectgene transfer vector transductionen_US
dc.subjectvector engineeringen_US
dc.titleThe Genetics of Primary Open Angle Glaucoma Interventions: Therapeutic Directions and Future Predictionsen_US
dc.typeJournal Articleen_US
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