In silico interaction of Berberine with some immunomodulatory targets: A docking analysis

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dc.contributor.authorGaneshpurkar, Adityaen_US
dc.contributor.authorChaturvedi, Amanen_US
dc.contributor.authorShrivastava, Abhisheken_US
dc.contributor.authorDubey, Nazneenen_US
dc.contributor.authorJain, Swatien_US
dc.contributor.authorSaxena, Nischalen_US
dc.contributor.authorGupta, Pratiken_US
dc.contributor.authorMujariya, Rajeshen_US
dc.date.accessioned2023-08-09T06:02:01Z
dc.date.available2023-08-09T06:02:01Z
dc.date.issued2022-08
dc.description.abstractPlant, mineral, and animal products have been utilized as medications from the beginning of time to cure a variety of ailments. Use of medicinal herbs to modulate immune function has a rich history. Natural products serve as the foundation for contemporary pharmaceutical ingredients. Immunomodulation alters an individual's immune system by interfering with its normal processes. Immunomodulators derived from natural sources have been extensively studied in order to modify the immune system and prevent illness. Berberine is an alkaloid has been identified for its anti-inflammatory properties. In animal studies, Berberine was found to demonstrate analgesic properties. The current work is aimed to explore the in silico interactions of Berberine with various chemokines and inflammatory pathways. Berberine was docked with TNF-?, IL-1?, IL-6, and NOs in this investigation. Docking study demonstrated notable interactions with these targets. The present research provides insight into the development of new compounds for immunomodulation and the management of inflammatory illnesses. More research on Berberine and related flavonoids is necessary to assess its safety. As a result, Berberine can be regarded as a candidate for the advancement of an immunomodulatory agent.en_US
dc.identifier.affiliationsDepartment of Pharmacologyen_US
dc.identifier.affiliationsDepartment of Medicinal Chemistry, Shri Ram Institute of Technology-Pharmacy-482 002, Jabalpur, Madhya Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Computer Science, Shri Ram Institute of Science & Technology, Jabalpur-482 002, Madhya Pradesh, Indiaen_US
dc.identifier.affiliationsInstitute of Pharmaceutical Science & Research (IPSR), Sardar Patel University, Balaghat-481 331, Madhya Pradesh, Indiaen_US
dc.identifier.citationGaneshpurkar Aditya, Chaturvedi Aman, Shrivastava Abhishek, Dubey Nazneen, Jain Swati, Saxena Nischal, Gupta Pratik, Mujariya Rajesh. In silico interaction of Berberine with some immunomodulatory targets: A docking analysis. Indian Journal of Biochemistry & Biophysics. 2022 Aug; 59(8): 848-853en_US
dc.identifier.issn0019-5189
dc.identifier.issn0975-1009
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/221566
dc.languageenen_US
dc.publisherCSIR-NIScPRen_US
dc.relation.issuenumber8en_US
dc.relation.volume59en_US
dc.source.urihttps://doi.org/10.56042/ijbb.v59i8.62908en_US
dc.subjectBerberineen_US
dc.subjectCytokinesen_US
dc.subjectImmunomodulatoryen_US
dc.subjectInflammationen_US
dc.subjectNitric oxideen_US
dc.titleIn silico interaction of Berberine with some immunomodulatory targets: A docking analysisen_US
dc.typeJournal Articleen_US
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