Assessment of cervicovaginal smear and HPV DNA co-test for cervical cancer screening: implications for diagnosis and follow-up strategies

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dc.contributor.authorShaheen, Nen_US
dc.contributor.authorAfrin, SSen_US
dc.contributor.authorRipon, MRKen_US
dc.contributor.authorNahar, Ken_US
dc.contributor.authorKhan, AAen_US
dc.contributor.authorHaque, S.en_US
dc.date.accessioned2025-05-12T07:25:28Z
dc.date.available2025-05-12T07:25:28Z
dc.date.issued2024-10
dc.description.abstractBackground: Cancer of the cervix, despite being a preventable disease, continues to be a significant public health problem in females. In recent years, much new development has taken place in the field of screening, diagnosis and management of cervical intraepithelial neoplasia. Methods: A total of 980 patients aged between 20 to 60 years were included in the study. All the patients have gone through Pap test, RT-PCR for HPV test and colposcopy biopsy. Then the sensitivity and specificity are calculated. Retrospectively selected Pap specimens with RT-PCR HPV testing results obtained from the Department of Pathology of Sheikh Fozilatunnessa Mujib Memorial KPJ Specialized Hospital, Gazipur, Bangladesh from July 2022 to July 2024 followed by the result is correlated with Colposcopy guided biopsy. Results: We found 250 cases of human papilloma virus RT-PCR positive, 433 cases of Pap test positive result and 399 cases of positive colposcopy biopsy result. So, The HPV test was demonstrated to be more sensitive (75%) than specific (55%) and was more sensitive than colposcopy for detecting CIN changes (75% vs. 73%). Conclusion: HPV tests showed a higher sensitivity than colposcopy, but colposcopy results presented higher specificity. Combining HPV testing and colposcopy proved to be the most efficient method for detecting CIN lesions.en_US
dc.identifier.affiliationsDepartment of Pathology, Sheikh Fozilatunnessa Mujib Memorial KPJ Specialized Hospital, Gazipur, Bangladeshen_US
dc.identifier.affiliationsDepartment of Pathology, Dhaka Medical College, Dhaka Bangladeshen_US
dc.identifier.affiliationsOral and Maxillofacial Surgery Department, Military Dental Center, Sylhet, Bangladeshen_US
dc.identifier.affiliationsDepartment of Microbiology and Virology, Sheikh Fozilatunnessa Mujib Memorial KPJ Specialized Hospital, Gazipur, Bangladeshen_US
dc.identifier.affiliationsDepartment of Pathology, Sheikh Fozilatunnessa Mujib Memorial KPJ Specialized Hospital, Gazipur, Bangladeshen_US
dc.identifier.affiliationsDepartment of Pathology, Bangladesh Medical College, Dhaka, Bangladeshen_US
dc.identifier.citationShaheen N, Afrin SS, Ripon MRK, Nahar K, Khan AA, Haque S.. Assessment of cervicovaginal smear and HPV DNA co-test for cervical cancer screening: implications for diagnosis and follow-up strategies . International Journal of Research in Medical Sciences. 2024 Oct; 12(10): 3641-3647en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/246838
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber10en_US
dc.relation.volume12en_US
dc.source.urihttps://doi.org/10.18203/2320-6012.ijrms20242921en_US
dc.subjectReal-time polymerase chain reactionen_US
dc.subjectAtypical squamous cells of undetermined significanceen_US
dc.subjectHuman papillomavirusen_US
dc.subjectCervical intraepithelial neoplasmen_US
dc.titleAssessment of cervicovaginal smear and HPV DNA co-test for cervical cancer screening: implications for diagnosis and follow-up strategiesen_US
dc.typeJournal Articleen_US
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