Efficacy of hydrocortisone acetate/hyaluronidase vs triamcinolone acetonide/hyaluronidase in the treatment of oral submucous fibrosis.

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dc.contributor.authorSingh, Mangal
dc.contributor.authorNiranjan, H S
dc.contributor.authorMehrotra, Ravi
dc.contributor.authorSharma, Devashish
dc.contributor.authorGupta, S C
dc.date.accessioned2011-11-25T05:13:29Z
dc.date.available2011-11-25T05:13:29Z
dc.date.issued2010-05
dc.description.abstractBackground & objective: Oral submucous fibrosis is a common premalignant condition caused by chewing arecanut and other irritants in various forms. Its medical treatment is not yet fully standardized, although the optimal doses of its medical treatment is in the form of hydrocortisone acetate combined with hyaluronidase. The problem with the prevailing treatment was injections at weekly interval. In this study we compared the efficacy of hydrocortisone acetate and hyaluronidase at weekly interval versus triamcinolone acetonide and hyaluronidase at 15 days interval. Methods: Patients of OSMF (100) were randomly divided into two groups A and B. Group A patients received combination of hydrocortisone acetate (1.5 ml)/hyaluronidase (1500 IU) at weekly interval submucosally in pterygomandibular raphe, half dose on each side for 22 wk. Group B patients received combination of triamcinolone acetonide (10 mg/ml)/ hyaluronidase (1500 IU) at 15 days interval for 22 wk. Treatment outcome was evaluated on the basis of improvement in symptom score, sign score and histopathological improvement. Student’s ‘t’ test was applied for comparing the results. Results: No statistically significant difference in symptom score, sign score and histopathological improvement was seen between the two groups. Interpretation & conclusion: Treatment regimen of group B was more convenient to the patients because less number of visits required and cheap. No side effects were seen. A follow up study is required to see long term effects.en_US
dc.identifier.citationSingh Mangal, Niranjan H S, Mehrotra Ravi, Sharma Devashish, Gupta S C. Efficacy of hydrocortisone acetate/hyaluronidase vs triamcinolone acetonide/hyaluronidase in the treatment of oral submucous fibrosis. Indian Journal of Medical Research. 2010 May; 131(5): 665-669.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/135497
dc.language.isoenen_US
dc.source.urihttps://icmr.nic.in/ijmr/2010/may/12.pdfen_US
dc.subjectHyaluronidaseen_US
dc.subjecthydrocortisone acetateen_US
dc.subjectoral submucous fibrosisen_US
dc.subjecttiamcinolone acetonideen_US
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshFemale
dc.subject.meshFibrosis --drug therapy
dc.subject.meshHumans
dc.subject.meshHyaluronoglucosaminidase --administration & dosage
dc.subject.meshHyaluronoglucosaminidase --therapeutic use
dc.subject.meshHydrocortisone --administration & dosage
dc.subject.meshHydrocortisone --analogs & derivatives
dc.subject.meshHydrocortisone --therapeutic use
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshMouth Diseases --drug therapy
dc.subject.meshMucous Membrane
dc.subject.meshProspective Studies
dc.subject.meshSingle-Blind Method
dc.subject.meshTriamcinolone Acetonide --administration & dosage
dc.subject.meshTriamcinolone Acetonide --therapeutic use
dc.subject.meshYoung Adult
dc.titleEfficacy of hydrocortisone acetate/hyaluronidase vs triamcinolone acetonide/hyaluronidase in the treatment of oral submucous fibrosis.en_US
dc.typeArticleen_US
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