Sjögren-like syndrome after bone marrow transplantation.

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dc.contributor.authorKosrirukvongs, Panidaen_US
dc.contributor.authorChirapapaisan, Niphonen_US
dc.contributor.authorVisuthisakchai, Sananen_US
dc.contributor.authorIssaragrisil, Surapolen_US
dc.contributor.authorGonggetyai, Vanngarmen_US
dc.date.accessioned2009-05-27T18:56:38Z
dc.date.available2009-05-27T18:56:38Z
dc.date.issued2008-11-09en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractOBJECTIVE: To study the incidence of dry eye in Sjögren-like syndrome, graft-versus-host disease (GVHD) in hematological patients undergoing bone marrow transplantation (BMT). MATERIAL AND METHOD: Prospective, cross-sectional study in twenty-six patients that were planned for BMT (group I). Twenty-nine patients undergoing BMT before study were classified as group II no GVHD (9), and group III with GVHD (20). Thirty-two normal subjects were controls. All subjects were examined by slit lamp biomicroscopy and had their tear samples analyzed about tear osmolarity. They were also evaluated for aqueous tear production by phenol red thread test, Schirmer test without anesthesia, tear film stability by tear break-up time (TBUT), and rose bengal staining 2 weeks before BMT (for group I) as well as 6 weeks, 3 months, and 6 months after BMT. The patients with GVHD were followed up 1 month later. Main outcome measures were amount of tear production, tear film stability, and dry eye symptoms. RESULTS: Average aqueous tear production in group III was less than control and group II (p < 0.001). Mean TBUT in group III was faster than control (p < 0.001) and group I before BMT (p = 0.001). Mean score of rose bengal staining in group III was more than control and group I before BMT (p < 0.001). Keratoconjunctivitis sicca and red eye developed in 27.5%, and 20% of group III, with incidence of dry eye by Schirmer test without anesthesia (67.5%). This compares with group II having incidence of dry eye of 16.7%. However, 42.3% of group I before BMT had dry eye compared with 9.4% in the controls (p < 0.001). CONCLUSION: Trend of dry eye in patients with BMT and GVHD were higher than no-GVHD group. Doctors should be aware of ocular symptoms and signs of dry eye in patients with BMT and follow-up for proper management.en_US
dc.description.affiliationDepartment of Ophthalmology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. sipks@mahidol.ac.then_US
dc.identifier.citationKosrirukvongs P, Chirapapaisan N, Visuthisakchai S, Issaragrisil S, Gonggetyai V. Sjögren-like syndrome after bone marrow transplantation. Journal of the Medical Association of Thailand. 2008 Nov; 91(11): 1739-47en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/40161
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAcute Diseaseen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshBone Marrow Transplantation --adverse effectsen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChronic Diseaseen_US
dc.subject.meshCross-Sectional Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshGraft vs Host Disease --etiologyen_US
dc.subject.meshHealth Status Indicatorsen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshKeratoconjunctivitis --etiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPhenolsulfonphthalein --diagnostic useen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSjogren's Syndrome --diagnosisen_US
dc.subject.meshYoung Adulten_US
dc.titleSjögren-like syndrome after bone marrow transplantation.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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