Correlation of Iron Deficiency Status with Thyroid Profile among Subclinical and Overt Hypothyroidism Patients Attending a Tertiary Care Hospital in Puducherry, India: A Cross-sectional Study

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dc.contributor.authorSylus, Angel Mercyen_US
dc.contributor.authorPriyatharshini, M.en_US
dc.contributor.authorMuraliswaran, P.en_US
dc.contributor.authorLavanya, M.en_US
dc.date.accessioned2025-05-09T10:44:59Z
dc.date.available2025-05-09T10:44:59Z
dc.date.issued2024-09
dc.description.abstractIntroduction: Hypothyroidism and iron deficiency are both highly prevalent disorders that share certain similar clinical presentations, implying the possibility for their coexistence. Hence, the objectives of this study were to evaluate serum iron indices and thyroid function tests in subclinical and overt hypothyroidism compared to healthy controls and to investigate the relationship between iron indices and thyroid function in subclinical and overt hypothyroidism. Materials and Methods: This hospital?based cross?sectional study included 154 participants, aged between 25–60 years, grouped as 46 subclinical hypothyroid patients, 58 overt hypothyroid patients, and 50 healthy controls. Their serum thyroid function and iron indices, namely ferritin, iron, total iron?binding capacity (TIBC), and transferrin saturation (TSAT), were estimated and compared between the groups. Results: The mean age of participants was 37.76 ± 7.13 years. Serum ferritin, iron, and TSAT were significantly lower, while TIBC was higher, in both the subclinical and overt hypothyroid groups compared to healthy subjects. In subclinical and overt hypothyroidism, thyroid?stimulating hormone showed a significant negative correlation with ferritin, iron, and TSAT, but positively correlated with TIBC. Free thyroxine correlated positively with ferritin, iron, and TSAT in both the hypothyroid groups but correlated negatively with TIBC in overt hypothyroidism only. Free triiodothyronine showed a positive correlation with ferritin in overt hypothyroidism. Conclusion: The study results suggest that iron deficiency correlates with thyroid function in both subclinical and overt hypothyroidism, demonstrated by decline in ferritin, iron, and TSAT with an increase in TIBC. It implies the likely coexistence of iron deficiency with subclinical and overt hypothyroidism and emphasizes the necessity for early assessment of iron status in patients with thyroid hypofunction to ensure appropriate management.en_US
dc.identifier.affiliationsDepartment of Biochemistry, Sri Venkateshwaraa Medical College Hospital and Research Centre, Puducherry, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, Sri Venkateshwaraa Medical College Hospital and Research Centre, Puducherry, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, Mahatma Gandhi Medical College and Research Institute, Puducherry, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Sri Venkateshwaraa Medical College Hospital and Research Centre, Puducherry, Indiaen_US
dc.identifier.citationSylus Angel Mercy, Priyatharshini M., Muraliswaran P., Lavanya M.. Correlation of Iron Deficiency Status with Thyroid Profile among Subclinical and Overt Hypothyroidism Patients Attending a Tertiary Care Hospital in Puducherry, India: A Cross-sectional Study. Acta Medica International. 2024 Sep; 11(3): 197-202en_US
dc.identifier.issn2349-0578
dc.identifier.issn2349-0896
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/245742
dc.languageenen_US
dc.publisherWolters Kluwer – Medknowen_US
dc.relation.issuenumber3en_US
dc.relation.volume11en_US
dc.source.urihttps://doi.org/10.4103/amit.amit_88_24en_US
dc.subjectFerritinen_US
dc.subjecthypothyroidismen_US
dc.subjectironen_US
dc.subjectiron deficiencyen_US
dc.subjectovert hypothyroidismen_US
dc.subjectsubclinical hypothyroidismen_US
dc.subjecttotal iron?binding capacityen_US
dc.subjecttransferrin saturationen_US
dc.titleCorrelation of Iron Deficiency Status with Thyroid Profile among Subclinical and Overt Hypothyroidism Patients Attending a Tertiary Care Hospital in Puducherry, India: A Cross-sectional Studyen_US
dc.typeJournal Articleen_US
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