Limited duration acedapsone prophylaxis in leprosy.

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dc.contributor.authorNeelan, P Nen_US
dc.contributor.authorSirumban, Pen_US
dc.contributor.authorSivaprasad, Nen_US
dc.date.accessioned1986-04-01en_US
dc.date.accessioned2009-05-28T09:40:31Z
dc.date.available1986-04-01en_US
dc.date.available2009-05-28T09:40:31Z
dc.date.issued1986-04-01en_US
dc.description.abstractA randomized controlled chemoprophylaxis trial was carried out in Madras city using 560 disease-free household child contacts of 264 multibacillary cases as study subjects. In the study, 13 cases were diagnosed among 280 contacts who received 3 injections of acedapsone at 10 weeks interval as against 30 cases among 280 contacts who had the same number of placebo injections, during the follow-up period of 225 weeks. The difference in the incidences in the two groups was statistically significant. (X2 6.45; P less than 0.02). The protection due to the limited duration of acedapsone prophylaxis was 56.7 percent. There were no cases of multi-bacillary leprosy in either group. The efficacy of prophylaxis was significant in male children over 9 years of age and female children in the age-group 1-8 years. The other prognostic factors like the infectivity status of the index cases in the household and the duration of exposure to them could have possibly influenced the effectiveness of prophylaxis in preventing progression from infection to clinical disease among the subjects studied. Their effects could not be assessed in this study.en_US
dc.identifier.citationNeelan PN, Sirumban P, Sivaprasad N. Limited duration acedapsone prophylaxis in leprosy. Indian Journal of Leprosy. 1986 Apr-Jun; 58(2): 251-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/54241
dc.language.isoengen_US
dc.subject.meshAcedapsone --therapeutic useen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAnalysis of Varianceen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshClinical Trials as Topicen_US
dc.subject.meshDapsone --analogs & derivativesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshLeprosy --prevention & controlen_US
dc.subject.meshMaleen_US
dc.subject.meshSex Factorsen_US
dc.subject.meshTime Factorsen_US
dc.titleLimited duration acedapsone prophylaxis in leprosy.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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