Estradiol induced vaginal cornification in spayed rats: a model to study hepatic microsomal enzyme induction.

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dc.contributor.authorShanbhag, T Ven_US
dc.contributor.authorBairy, K Len_US
dc.contributor.authorKulkarni, D Ren_US
dc.date.accessioned1989-01-01en_US
dc.date.accessioned2009-06-01T07:39:57Z
dc.date.available1989-01-01en_US
dc.date.available2009-06-01T07:39:57Z
dc.date.issued1989-01-01en_US
dc.description.abstractUtilizing vaginal cornification as a response for bioassay, a study was conducted to observe the variation in the median cornification dose (cED50) of estradiol, a hepatic-first-pass candidate, given either ip or sc in spayed rats, with or without enzyme induction by rifampin. Comparisons within and between the groups showed that after enzyme induction cED50 was increased fourfold and cED50 ip/cED50 sc ratio was doubled. The findings clearly demonstrate that this animal model faithfully reflects alterations in hepatic enzyme activity and could serve as an alternate for conventional hexobarbitone sleeping time test to study enzyme induction.en_US
dc.description.affiliationDepartment of Pharmacology, Kasturba Medical College, Manipal.en_US
dc.identifier.citationShanbhag TV, Bairy KL, Kulkarni DR. Estradiol induced vaginal cornification in spayed rats: a model to study hepatic microsomal enzyme induction. Indian Journal of Physiology and Pharmacology. 1989 Jan-Mar; 33(1): 31-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108328
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAnimalsen_US
dc.subject.meshEnzyme Induction --drug effectsen_US
dc.subject.meshEstradiol --administration & dosageen_US
dc.subject.meshFemaleen_US
dc.subject.meshInjections, Intraperitonealen_US
dc.subject.meshInjections, Subcutaneousen_US
dc.subject.meshMicrosomes, Liver --enzymologyen_US
dc.subject.meshOvariectomyen_US
dc.subject.meshRatsen_US
dc.subject.meshRifampin --pharmacologyen_US
dc.subject.meshVagina --drug effectsen_US
dc.titleEstradiol induced vaginal cornification in spayed rats: a model to study hepatic microsomal enzyme induction.en_US
dc.typeJournal Articleen_US
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