Antiretroviral treatment in resource-poor settings: a view from India.

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dc.contributor.authorVajpayee, Madhuen_US
dc.contributor.authorKaushik, Shwetaen_US
dc.contributor.authorMojumdar, Kamalikaen_US
dc.contributor.authorSreenivas, Ven_US
dc.date.accessioned2007-07-06en_US
dc.date.accessioned2009-05-29T05:58:39Z
dc.date.available2007-07-06en_US
dc.date.available2009-05-29T05:58:39Z
dc.date.issued2007-07-06en_US
dc.description.abstractCONTEXT: The introduction of highly effective generic antiretroviral drugs at reduced cost has transformed the face of HIV/AIDS epidemic in developing countries like India. However, there is an urgent emphasis on developing and implementing guidelines for antiretroviral treatment monitoring by laboratory methods utilizing the available technologies in resource-limited settings. AIM: We studied the efficacy of antiretroviral treatment, adherence to therapy and motivation of patients for regular treatment monitoring by CD4 counts. SETTINGS AND DESIGN: A longitudinal cohort study on an established cohort of 166 HIV-1-infected Indian individuals. MATERIALS AND METHODS: Study subjects were followed up for the period from January 2002 to November 2006. Their clinical status and treatment regimen were recorded and CD4 counts were performed at each visit. STATISTICAL ANALYSIS: Repeated-measures ANOVA was used to compute changes in median CD4 counts at each visit in the different treatment groups. RESULTS: We observed a growing awareness and motivation for regular HIV disease monitoring among patients, accompanied by a trend of increasing median CD4 counts at all subsequent follow-up visits after initiation of antiretroviral treatment. CONCLUSIONS: The study gives an insight into the institutional efforts for the establishment of cohorts for longitudinal studies, which will help in designing effective treatment guidelines, thus providing impetus to the free public sector antiretroviral therapy program in India. Such formative research aims to fill the lacunae in the limited available data for the formulation of treatment-monitoring guidelines in resource-poor settings of developing countries like India.en_US
dc.description.affiliationDepartment of Microbiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110 029, India. mvajpayee@hotmail.comen_US
dc.identifier.citationVajpayee M, Kaushik S, Mojumdar K, Sreenivas V. Antiretroviral treatment in resource-poor settings: a view from India. Indian Journal of Medical Sciences. 2007 Jul; 61(7): 390-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/68277
dc.language.isoengen_US
dc.source.urihttps://www.indianjmedsci.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshAnti-Retroviral Agents --therapeutic useen_US
dc.subject.meshCD4 Lymphocyte Counten_US
dc.subject.meshFemaleen_US
dc.subject.meshHIV Infections --drug therapyen_US
dc.subject.meshHIV-1en_US
dc.subject.meshHealth Resources --economicsen_US
dc.subject.meshHealth Services Accessibilityen_US
dc.subject.meshHealth Services Needs and Demanden_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshMaleen_US
dc.subject.meshPatient Complianceen_US
dc.subject.meshPovertyen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshSocioeconomic Factorsen_US
dc.titleAntiretroviral treatment in resource-poor settings: a view from India.en_US
dc.typeJournal Articleen_US
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