Prevalence of Extended Spectrum β-lactamases Producing Clinical Isolates from Patients of Urinary Tract Infection in a Tertiary Care Hospital in Delhi.
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Date
2008-12
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Abstract
A total of 250 urinary isolates (188 Escherichia coli and 62 Klebsiella
pneumoniae) were studied for ESBL production by double disc
approximation test and disc diffusion confirmatory test (NCCLS). ESBL
production was found to be 56% in E. coli and 52% in K. pneumoniae. The
double disc approximation test showed false ESBL production in five (2.6%)
isolates of E. coli and one (1.6%) K.pneumoniae. The susceptibility of ESBL
producers to imipenem, amikacin, nitrofurantion was found to be 100%,
86% and 84% respectively. A high degree of co-resistance to co- trimaxazole
and norfloxacin was found in strains of ESBL producers.
Seventy five per cent of ESBL producers detected were from hospitalized
patients admitted in ICU or undergoing surgery.
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Keywords
ESBL, Escherichia coli, Klebsiella pneumoniae
Citation
Malhotra V L, Khandpur N, Dass A, Mehta G. Prevalence of Extended Spectrum β-lactamases Producing Clinical Isolates from Patients of Urinary Tract Infection in a Tertiary Care Hospital in Delhi. Journal of Communicable Diseases. 2008 Dec; 40(4): 269-272.