Cisplatin-based chemotherapy: Add high-frequency audiometry in the regimen.

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dc.contributor.authorArora, R
dc.contributor.authorThakur, J S
dc.contributor.authorAzad, R K
dc.contributor.authorMohindroo, N K
dc.contributor.authorSharma, D R
dc.contributor.authorSeam, R K
dc.date.accessioned2013-01-10T08:20:42Z
dc.date.available2013-01-10T08:20:42Z
dc.date.issued2009-10
dc.description.abstractBackground : Cisplatin-induced ototoxicity shows high interindividual variability and is often accompanied by transient or permanent tinnitus. It is not possible to identify the susceptible individuals before commencement of the treatment. We conducted a prospective, randomized and observational study in a tertiary care centre and evaluated the effects of different doses of cisplatin on hearing. Materials and Methods : Fifty-seven patients scheduled for cisplatin-based chemotherapy were included in the study. All patients were divided into three groups depending on the dose of cisplatin infused in 3 weeks. Results : The subjective hearing loss was found in seven patients, while six patients had tinnitus during the chemotherapy. The hearing loss was sensorineural, dose dependent, symmetrical, bilateral and irreversible. Higher frequencies were first to be affected in cisplatin chemotherapy. Conclusion : As use of high-frequency audiometry is still limited in research work only, we need a strict protocol of adding high-frequency audiometry in the cisplatin-based chemotherapy regimen.en_US
dc.identifier.citationArora R, Thakur J S, Azad R K, Mohindroo N K, Sharma D R, Seam R K. Cisplatin-based chemotherapy: Add high-frequency audiometry in the regimen. Indian Journal of Cancer. 2009 Oct-Dec; 46(4): 311-317.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/144267
dc.language.isoenen_US
dc.source.urihttps://www.indianjcancer.com/article.asp?issn=0019-509X;year=2009;volume=46;issue=4;spage=311;epage=317;aulast=Aroraen_US
dc.subjectAudiometryen_US
dc.subjectcisplatinen_US
dc.subjecthearing lossen_US
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshAntineoplastic Agents --administration & dosage
dc.subject.meshAudiometry
dc.subject.meshCisplatin --administration & dosage
dc.subject.meshDose-Response Relationship, Drug
dc.subject.meshFemale
dc.subject.meshHearing Loss --chemically induced
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshNeoplasms --drug therapy
dc.subject.meshTinnitus --chemically induced
dc.subject.meshYoung Adult
dc.titleCisplatin-based chemotherapy: Add high-frequency audiometry in the regimen.en_US
dc.typeArticleen_US
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