The renal pathology in children dying with hepatic cirrhosis.

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dc.contributor.authorShet, Tanujaen_US
dc.contributor.authorKandalkar, Bhuvaneshwarien_US
dc.contributor.authorBalasubramaniam, Meenakshien_US
dc.contributor.authorPhatak, Anuradhaen_US
dc.date.accessioned2002-01-21en_US
dc.date.accessioned2009-05-29T12:51:09Z
dc.date.available2002-01-21en_US
dc.date.available2009-05-29T12:51:09Z
dc.date.issued2002-01-21en_US
dc.description.abstractThe aim of this analysis was to observe the pathologic changes in the kidney in 23 children dying of cirrhosis, including five children with renal failure. Besides these pathologic changes, glomerular cellularity and arteriolar wall thickness of these patients were compared with 18 age matched autopsy controls dying of nonhepatic and nonrenal causes. Histologic examination of the kidneys in these cirrhotic children showed significant tubular changes in five patients, diffuse glomerulosclerosis in five, only one child had membranous glomerulopathy or glomerulonephritis and one cirrhotic with serum hepatitis B surface antigen positivity had polyarteritis nodosa. No statistically significant changes were observed in the glomerular cellularity and the arteriolar wall thickness in these cirrhotic children as compared to the controls. However, medial proliferation and hyaline arteriolosclerosis were observed in four cirrhotic children. Tubular bile casts and nephrocalcinosis were the sole lesions causing renal failure in two cases. A combination of glomerulosclerosis, cast formation and arteriolosclerosis was seen in the remaining three patients. Thus the kidney showed a spectrum of pathology in pediatric cirrhosis. The tubular lesions causing renal failure represent acute treatable lesions whereas glomerulosclerosis and arteriosclerosis stand for a more chronic and less reversible renal damage.en_US
dc.description.affiliationDepartment of Pathology, BYL Nair Ch. Hospital and TN Medical College, Mumbai Central, Mumbai, India.en_US
dc.identifier.citationShet T, Kandalkar B, Balasubramaniam M, Phatak A. The renal pathology in children dying with hepatic cirrhosis. Indian Journal of Pathology & Microbiology. 2002 Jan; 45(1): 39-43en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/75031
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshHumansen_US
dc.subject.meshInfanten_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshKidney --pathologyen_US
dc.subject.meshKidney Diseases --pathologyen_US
dc.subject.meshKidney Failure --pathologyen_US
dc.subject.meshKidney Glomerulus --pathologyen_US
dc.subject.meshLiver Cirrhosis --complicationsen_US
dc.subject.meshTerminally Illen_US
dc.titleThe renal pathology in children dying with hepatic cirrhosis.en_US
dc.typeJournal Articleen_US
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