Investigations on remedial role of Rauwolfia serpentina root extract against carbofuran formulation induced genotoxicity in Channa punctatus

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dc.contributor.authorTiwari, V.en_US
dc.contributor.authorTrivedi, S.P.en_US
dc.date.accessioned2020-11-18T10:16:19Z
dc.date.available2020-11-18T10:16:19Z
dc.date.issued2019-09
dc.description.abstractAim: To investigate the remedial potential of Rauwolfia serpentina root extract against genotoxic alterations induced by exposure of carbofuran formulation in freshwater teleost, Channa punctatus. Methodology: Ten days acclimatized fish were categorized in three groups, Group 1 (control), Group 2 (0.09 mg l-1 carbofuran formulation) and group 3 (0.09 mg l-1 carbofuran formulation +10 ppm ethanolic extract of Rauwolfia serpentina). Genotoxic alterations were recorded in terms of single cell gel electrophoresis (SCGE) and micronucleus (MN) assay in blood cells. The variation in comet tail length and micronuclei frequencies were compared among Group 1, 2 and 3 after 24, 48, 72 and 96 hr. Results: A significant (p<0.05) increase was observed in comet tail length and micronuclei induction in carbofuran formulation exposed group. The longest comet length and peak of micronuclei frequencies were observed after 96 hr of carbofuran formulation exposure. However, an appreciable and gradual decline in both frequencies of micronuclei and comet tail length were observed in group 3 (combined Carbofuran formulation and Rauwolfia serpentina root extract) in comparison to group 2 (Carbofuran formulation). Interpretation: The study, thus, demonstrates ameliorative potential of Rauwolfia serpentina root extract against carbofuran formulation induced genotoxicity in fish.en_US
dc.identifier.affiliationsInstitute of Food Processing and Technology, ONGC Center of Advanced Studies, University of Lucknow, Lucknow-226 007, Indiaen_US
dc.identifier.affiliationsEnvironmental Toxicology and Bioremediation Laboratory, Department of Zoology,University of Lucknow,Lucknow-226 007, Indiaen_US
dc.identifier.citationTiwari V., Trivedi S.P.. Investigations on remedial role of Rauwolfia serpentina root extract against carbofuran formulation induced genotoxicity in Channa punctatus. Journal of Environmental Biology . 2019 Sep; 40(5): 1023-1028en_US
dc.identifier.issn0254-8704
dc.identifier.issn2394-0379
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/214621
dc.languageenen_US
dc.publisherTriveni Enterprisesen_US
dc.relation.issuenumber5en_US
dc.relation.volume40en_US
dc.source.urihttps://www.jeb.co.in/journal_issues/201909_sep19/paper_06.pdfen_US
dc.subjectChanna punctatusen_US
dc.subjectCarbofuran toxicityen_US
dc.subjectMicronucleus assayen_US
dc.subjectRauwolfia serpentinaen_US
dc.titleInvestigations on remedial role of Rauwolfia serpentina root extract against carbofuran formulation induced genotoxicity in Channa punctatusen_US
dc.typeJournal Articleen_US
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