Protective role of Cassia auriculata leaf extract on hyperglycemia-induced oxidative stress and its safety evaluation.

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dc.contributor.authorGupta, Shipra
dc.contributor.authorSharma, Suman Bala
dc.contributor.authorPrabhu, Krishna Madhava
dc.contributor.authorBansal, Surendra Kumar
dc.date.accessioned2011-11-11T05:17:45Z
dc.date.available2011-11-11T05:17:45Z
dc.date.issued2009-10
dc.description.abstractCassia auriculata L. (Caesalpiniaceae) is widely used from the ancient period to treat diabetes mellitus. In the present study, the antioxidant activity of C. auriculata aqueous leaf extract (CLEt) was evaluated in streptozotocin-induced mild diabetic (MD) and severe diabetic (SD) rats. A short-term toxicity assessment was also conducted in healthy rats to examine toxic effects of the extract. Oral administration of CLEt to MD and SD rats (100, 200 and 400 mg/kg body weight per day for a period of 21 days) produced significant fall in fasting blood glucose (FBG) in a dose-dependent manner. Treatment with the extract (400 mg/kg) showed significant reduction in serum levels of thiobarbituric acid reactive substances (TBARS) and oxidized low-density lipoprotein (OxLDL) in both MD and SD rats. The antioxidant defense system was also found to be improved in CLEt-treated (400 mg/kg) MD and SD rats, as revealed by significant increase in activities of erythrocyte’s antioxidant enzymes i.e. superoxide dismutase (SOD) and catalase (CAT) with a concomitant elevation in erythrocyte’s reduced glutathione (GSH) content. Moreover, there were no toxic signs in rats treated with high doses of the extract (1000 and 2000 mg/kg body weight per day for 21 days). Blood glucose, hepatic and renal function parameters in these rats were found within normal limits. Phytochemical screening of CLEt revealed the presence of alkaloids, flavonoids, saponins, tannins and cardiac glycosides with antihyperglycemic and antioxidant properties. This study suggests that CLEt possesses potent antioxidant activity along with antihyperglycemic potential, hence protective against diabetic complications.en_US
dc.identifier.citationGupta Shipra, Sharma Suman Bala, Prabhu Krishna Madhava, Bansal Surendra Kumar. Protective role of Cassia auriculata leaf extract on hyperglycemia-induced oxidative stress and its safety evaluation. Indian Journal of Biochemistry & Biophysics. 2009 Oct; 46(5): 371-377.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/135219
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/bitstream/123456789/6294/1/IJBB%2046%285%29%20371-377.pdfen_US
dc.subjectCassia auriculataen_US
dc.subjectDiabetes mellitusen_US
dc.subjectStreptozotocinen_US
dc.subjectPhytochemicalsen_US
dc.subjectAntioxidant activityen_US
dc.subjectToxicity assessmenten_US
dc.subject.meshAnimals
dc.subject.meshCassia --chemistry
dc.subject.meshCatalase --metabolism
dc.subject.meshDiabetes Mellitus, Experimental --chemically induced
dc.subject.meshDiabetes Mellitus, Experimental --drug therapy
dc.subject.meshDiabetes Mellitus, Experimental --metabolism
dc.subject.meshDrug Toxicity
dc.subject.meshGlutathione --metabolism
dc.subject.meshHyperglycemia --chemically induced
dc.subject.meshHyperglycemia --metabolism
dc.subject.meshLipoproteins, LDL --metabolism
dc.subject.meshMale
dc.subject.meshOxidative Stress --drug effects
dc.subject.meshPlant Extracts --adverse effects
dc.subject.meshPlant Extracts --pharmacology
dc.subject.meshPlant Extracts --therapeutic use
dc.subject.meshPlant Leaves --chemistry
dc.subject.meshRats
dc.subject.meshRats, Wistar
dc.subject.meshSuperoxide Dismutase --metabolism
dc.subject.meshThiobarbituric Acid Reactive Substances --metabolism
dc.titleProtective role of Cassia auriculata leaf extract on hyperglycemia-induced oxidative stress and its safety evaluation.en_US
dc.typeArticleen_US
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