Antitumour effect of abrin on transplanted tumours in mice.

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dc.contributor.authorRamnath, Ven_US
dc.contributor.authorKuttan, Girijaen_US
dc.contributor.authorKuttan, Ramadasanen_US
dc.date.accessioned2002-01-25en_US
dc.date.accessioned2009-06-01T05:04:28Z
dc.date.available2002-01-25en_US
dc.date.available2009-06-01T05:04:28Z
dc.date.issued2002-01-25en_US
dc.description.abstractAbrin, a galactose specific lectin was purified using sepharose 4B affinity column from seeds of Abrus precatorius. It exhibited antitumour activity in mice when used at a sublethal dose of 7.5 micrograms/kg every alternate day for 10 days. Both intralesional and intraperiloneal (i.p.) administration of abrin was effective in reducing solid tumour mass development induced by Dalton's Lymphoma Ascites (DLA) and Ehrlich's Ascites Carcinoma (EAC) cells. DLA cell line was more sensitive to abrin than EAC. Abrin when injected i.p. increased the life span of ascites tumour bearing mice. Abrin when used simultaneously with tumour cells brought about maximum antitumour effect. On developed tumour masses, abrin administration brought about significant reduction in tumour volume, especially in DLA induced tumours. Prophylactic administration of abrin was found ineffective.en_US
dc.description.affiliationDepartment of Physiology, College of Veterinary and Animal Sciences, Mannuthy, Thrissur-680 651.en_US
dc.identifier.citationRamnath V, Kuttan G, Kuttan R. Antitumour effect of abrin on transplanted tumours in mice. Indian Journal of Physiology and Pharmacology. 2002 Jan; 46(1): 69-77en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/106331
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAbrin --pharmacologyen_US
dc.subject.meshAbrusen_US
dc.subject.meshAnimalsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshFemaleen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred BALB Cen_US
dc.subject.meshPhytotherapy --methodsen_US
dc.subject.meshPlant Extracts --pharmacologyen_US
dc.subject.meshSeedsen_US
dc.subject.meshTumor Cells, Cultured --drug effectsen_US
dc.subject.meshXenograft Model Antitumor Assays --methodsen_US
dc.titleAntitumour effect of abrin on transplanted tumours in mice.en_US
dc.typeJournal Articleen_US
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