Thyrotoxicosis in children: treatment and outcome.

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dc.contributor.authorJaruratanasirikul, Somchiten_US
dc.contributor.authorLeethanaporn, Kalayaen_US
dc.contributor.authorSriplung, Hutchaen_US
dc.date.accessioned2009-05-27T19:40:46Z
dc.date.available2009-05-27T19:40:46Z
dc.date.issued2006-07-03en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractOBJECTIVES: To study the treatment modalities and the outcome of treatments of children with thyrotoxicosis or Graves' disease. MATERIAL AND METHOD: A retrospective study of 56 patients diagnosed with thyrotoxicosis from January 1992 to December 2004 was conducted. There were 44 girls and 12 boys (female to male ratio 3.7:1). The average age at diagnosis was 11.9 +/- 3.4 years. RESULTS: All patients were initially treated with antithyroid drugs, either propylthiouracil (n = 53) or methimazole (n = 3). All patients achieved euthyroidism within 8.4 +/- 3.3 weeks. Eleven patients are still on the treatment, and 45 patients have completed the treatment. Of these 45 patients, 38 (84.4%) remitted after antithyroid drug treatment of an average duration of 37.4 +/- 16.5 months (range 12-90), 4 patients (8.9%) chose radioactive iodine treatment and three patients (6.7%) underwent thyroidectomy. Of the 38 patients remitted with antithyroid drugs, eleven (28.9%) relapsed within 4-24 months. The relapsed patients remitted with a second course of antithyroid drugs in three patients, underwent radioactive iodine in seven patients, and thyroidectomy in one patient. Therefore, of the total 45 patients who had completed the treatment, 30 patients (66.7%) remitted with antithyroid drugs, eleven patients (24.4%) received radioactive iodine, and four patients (8.9%) underwent thyroidectomy. Using stepwise multivariate logistic regression, the authors could not identify any factors (including age, gender, family history of thyroid diseases, size of goiter, level of free T4, dosage and duration of antithyroid drugs) that would predict the remission of thyrotoxicosis with antithyroid drugs. CONCLUSION: Antithyroid drugs should remain the first-line therapy for treatment of thyrotoxicosis in children with a remission rate of 66.7%. The patients who are noncompliant or relapse after treatment with antithyroid drugs should be treated with radioactive iodine.en_US
dc.description.affiliationDepartment of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand. somchit.j@psu.ac.then_US
dc.identifier.citationJaruratanasirikul S, Leethanaporn K, Sriplung H. Thyrotoxicosis in children: treatment and outcome. Journal of the Medical Association of Thailand. 2006 Jul; 89(7): 967-73en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/41584
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdolescenten_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIodine Radioisotopes --therapeutic useen_US
dc.subject.meshLogistic Modelsen_US
dc.subject.meshMaleen_US
dc.subject.meshMethimazole --therapeutic useen_US
dc.subject.meshPropylthiouracil --therapeutic useen_US
dc.subject.meshRecurrenceen_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshThyroidectomyen_US
dc.subject.meshThyrotoxicosis --therapyen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleThyrotoxicosis in children: treatment and outcome.en_US
dc.typeJournal Articleen_US
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