High-Sensitivity C-Reactive Protein in Metabolic Healthy Obesity (MHO)..

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dc.contributor.authorRasheed, Aamilen_US
dc.contributor.authorAcharya, Souryaen_US
dc.contributor.authorShukla, Samarthen_US
dc.contributor.authorKumar, Sunilen_US
dc.contributor.authorYarappa, Roopeshen_US
dc.contributor.authorGupte, Yashen_US
dc.contributor.authorHulkoti, Vidyashreeen_US
dc.date.accessioned2020-11-18T10:18:51Z
dc.date.available2020-11-18T10:18:51Z
dc.date.issued2020-02
dc.description.abstractMetabolically Healthy Obesity/Metabolic Healthy Obesity (MHO) is a paradox in scientific medical literature and discussion is still on regarding the safety status of MHO phenotype. It is an obesity phenotype where the subjects have BMI more than or equal to 30 Kg/m2 but are devoid of conventional metabolic complications such deranged lipid profile, altered glucose tolerance, or metabolic syndrome as they have less adverse inflammatory profile, low visceral fat, less disturbed insulin signalling, and lipid metabolism. But recently studies are coming up with robust evidence that MHO is not a benign condition. It may lead to metabolic syndrome in future and it is also associated with cardiometabolic risks.METHODSThis cross-sectional study was done in a tertiary care hospital conducted for a period of two years from October 2017 to October 2019. After obtaining institutional ethical clearance, this cross-sectional study was conducted on 120 MHO subjects, 120 metabolic syndrome (MS) and 120 Metabolic Healthy Non-Obese (MHNO) subjects. Anthropometric data was obtained, and hs-CRP was estimated and compared with MS and MHNO group. The data was analysed using appropriate statistical significance tests.RESULTSIn one-way Analysis of Variance (ANOVA), anthropometric determinants and metabolic variables differed significantly across the groups (p<0.0001). The mean hs-CRP in MHO was; 4.45 ± 1.46 and in the control group it was 1.84 ± 0.77 (p<0.0001). Using Pearson’s correlation coefficient, significant positive correlation was found between hs-CRP with other anthropometric and metabolic parameters. In multiple regression analysis, Body Mass Index (BMI), Waist Circumference (WC), were significantly associated with elevated hs-CRP. Adjusted odd’s (AOR) of abnormal hs-CRP in MHO was 1.9 times that of MHNO subjects.CONCLUSIONSMHO phenotype is associated with increased hs-CRP levels as compared to MHNO phenotype suggesting that obesity even if associated with a healthy metabolic profile, still harbour subclinical inflammation. So, subjects with MHO should be targeted for appropriate preventive strategies in the form of health education, lifestyle alterations to avoid future cardiovascular morbidities. MHO phenotype with evidence of subclinical vascular inflammation should not be considered a benign condition.en_US
dc.identifier.affiliationsDepartment of Medicine, DMIMS (Deemed to be University) Sawangi (M), Wardha, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Medicine, DMIMS (Deemed to be University) Sawangi (M), Wardha, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, DMIMS (Deemed to be University) Sawangi (M), Wardha, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Medicine, DMIMS (Deemed to be University) Sawangi (M), Wardha, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Medicine, DMIMS (Deemed to be University) Sawangi (M), Wardha, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Medicine, DMIMS (Deemed to be University) Sawangi (M), Wardha, Maharashtra, Indiaen_US
dc.identifier.affiliationsDepartment of Medicine, DMIMS (Deemed to be University) Sawangi (M), Wardha, Maharashtra, India.en_US
dc.identifier.citationRasheed Aamil, Acharya Sourya, Shukla Samarth, Kumar Sunil, Yarappa Roopesh, Gupte Yash, Hulkoti Vidyashree. High-Sensitivity C-Reactive Protein in Metabolic Healthy Obesity (MHO)... Journal of Evolution of Medical and Dental Sciences. 2020 Feb; 9(7): 443-447en_US
dc.identifier.issn2278-4802
dc.identifier.issn2278-4748
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/215368
dc.languageenen_US
dc.publisherAkshantala Enterprises Private Limiteden_US
dc.relation.issuenumber7en_US
dc.relation.volume9en_US
dc.source.urihttps://dx.doi.org//10.14260/jemds/2020/100en_US
dc.subjectHigh Sensitivity C-Reactive Proteinen_US
dc.subjectMetabolic Syndromeen_US
dc.subjectMetabolic Healthy Non-Obeseen_US
dc.titleHigh-Sensitivity C-Reactive Protein in Metabolic Healthy Obesity (MHO)..en_US
dc.typeJournal Articleen_US
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