Role of doxycycline post exposure prophylaxis in the prevention of sexually transmitted infections: a narrative review

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dc.contributor.authorWaheed, Fen_US
dc.contributor.authorSher, Aen_US
dc.contributor.authorGul, Men_US
dc.contributor.authorNisa, Uen_US
dc.contributor.authorSaeed, A.en_US
dc.date.accessioned2025-05-12T08:25:53Z
dc.date.available2025-05-12T08:25:53Z
dc.date.issued2024-10
dc.description.abstractSexually transmitted infections (STIs) spread through sexual intercourse. They are caused by pathogens like Neisseria gonorrhoeae, Treponema pallidum, Chlamydia trachomatis, and Mycoplasma genitalium, and can be transmitted through direct contact or contact with genital secretions. Doxycycline is a second-generation tetracycline antibiotic with a broad antimicrobial spectrum, acting on intracellular and extracellular organisms. This review aims to explore the efficacy of doxycycline post-exposure prophylaxis (PEP) in the prevention and treatment of STIs. Some of the areas of uncertainty with the use of doxycycline PEP for STIs include the concern for developing antimicrobial resistance (AMR), the effect on the normal microbiome of the body, public acceptability, drug formulation and dosage and compliance issues. Recent clinical and observational studies have looked at using doxycycline PEP to reduce the transmission of STIs. This review aims to explore these studies to provide a comprehensive account of the current state of doxycycline PEP and its future prospects. We also look at the limitations and areas of improvement in using doxycycline PEP, opening avenues for future research. High-quality studies have shown that using doxycycline PEP can effectively reduce the transmission of STIs in a number of clinical trials as well as systematic reviews., making it a potential standard treatment for high-risk groups such as immunocompromised patients, individuals living with HIV, sex workers, and men who have sex with men (MSM).en_US
dc.identifier.affiliationsDepartment of Medicine, Hayatabad Medical Complex, Peshawar, Pakistanen_US
dc.identifier.affiliationsDepartment of Medicine, Khyber Medical College, Peshawar, Pakistanen_US
dc.identifier.affiliationsDepartment of Medicine, Hayatabad Medical Complex, Peshawar, Pakistanen_US
dc.identifier.affiliationsDepartment of Medicine, Khyber Teaching Hospital Peshawar, Pakistanen_US
dc.identifier.affiliationsDepartment of Medicine, Khyber Teaching Hospital Peshawar, Pakistanen_US
dc.identifier.citationWaheed F, Sher A, Gul M, Nisa U, Saeed A. . Role of doxycycline post exposure prophylaxis in the prevention of sexually transmitted infections: a narrative review . International Journal of Scientific Reports. 2024 Oct; 10(10): 365-368en_US
dc.identifier.issn2454-2156
dc.identifier.issn2454-2164
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/246992
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber10en_US
dc.relation.volume10en_US
dc.source.urihttps://doi.org/10.18203/issn.2454-2156.IntJSciRep20242695en_US
dc.subjectDoxycylineen_US
dc.subjectPEPen_US
dc.subjectSTIsen_US
dc.subjectPreventive medicineen_US
dc.titleRole of doxycycline post exposure prophylaxis in the prevention of sexually transmitted infections: a narrative reviewen_US
dc.typeJournal Articleen_US
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