Single dose oral clonidine premedication does not enhance postoperative, single low dose epidural morphine analgesia in hysterectomy patients.

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dc.contributor.authorOofuvong, Maliwanen_US
dc.contributor.authorChanvej, Laksameeen_US
dc.contributor.authorThongsuksai, Parameeen_US
dc.date.accessioned2009-05-27T19:19:01Z
dc.date.available2009-05-27T19:19:01Z
dc.date.issued2005-03-21en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractIn this randomized, double blind placebo controlled study, the authors evaluated the effects of oral clonidine premedication on very low dose epidural morphine analgesia in 50 hysterectomy patients. Patients were randomized to receive a single oral clonidine 300 microg (n = 25) or a placebo (n = 25) 90 minutes before insertion of the epidural catheter. 3 ml of 2% lidocaine with adrenaline (5 microg ml(-1) mixed with 2 mg morphine were injected via epidural, followed by an additional volume of 2% lidocaine with adrenaline (5 microg ml(-1)) titrated to T6 block height before commencing general anesthesia. The postoperative analgesia regimen was 2 mg of intravenous morphine every 10 minutes for the first 48 hr and 1 gm of oral acetaminophen every 4-6 hr after initiation of oral diet at 24-48 hr as required. Morphine consumption, acetaminophen, pain scores, and side effects were recorded thoughout 48 hr after surgery. The results show patients in the clonidine and placebo groups were not different in terms of local anesthetics dose (p = 0.27), total morphine and acetaminophen requirement (p = 0.34, p = 0.1) respectively. Pain scores at rest and movement were also not different in both groups (p = 0.83, p = 0.64) respectively. No serious adverse effects were noted. The authors concluded that oral clonidine approximately 6 microg kg(-1) does not enhance the analgesic effect of epidural morphine 2 mg after hysterectomy.en_US
dc.description.affiliationDepartment of Anesthesiology, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand. malewan@yahoo.comen_US
dc.identifier.citationOofuvong M, Chanvej L, Thongsuksai P. Single dose oral clonidine premedication does not enhance postoperative, single low dose epidural morphine analgesia in hysterectomy patients. Journal of the Medical Association of Thailand. 2005 Mar; 88(3): 358-63en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/40890
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdministration, Oralen_US
dc.subject.meshAdulten_US
dc.subject.meshAnalgesics --administration & dosageen_US
dc.subject.meshAnalgesics, Opioid --administration & dosageen_US
dc.subject.meshClonidine --administration & dosageen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshHysterectomyen_US
dc.subject.meshInjections, Epiduralen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMorphine --administration & dosageen_US
dc.subject.meshPremedication --methodsen_US
dc.subject.meshProspective Studiesen_US
dc.titleSingle dose oral clonidine premedication does not enhance postoperative, single low dose epidural morphine analgesia in hysterectomy patients.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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