Antiarthritic activity of Majoon Suranjan (a polyherbal Unani formulation) in rat.

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dc.contributor.authorSingh, Surender
dc.contributor.authorNair, Vinod
dc.contributor.authorGupta, Y K
dc.date.accessioned2011-12-09T08:21:17Z
dc.date.available2011-12-09T08:21:17Z
dc.date.issued2011-09
dc.description.abstractBackground & objectives: Majoon Suranjan (MS) is a polyherbal formulation used in Unani system of medicine for the treatment of rheumatoid arthritis (RA). The present study evaluates the antiarthritic efficacy of this formulation in three different experimental models. Methods: The anti-inflammatory activity of MS (in doses of 450, 900 and 1800 mg/kg body wt) was evaluated using the turpentine oil induced paw oedema model and the antiarthritic efficacy was evaluated using the formaldehyde and complete Freund's adjuvant (CFA) induced arthritis models. Aspirin (100 mg/kg body wt) was used as the standard drug in all the models. In order to assess the safety of the test drug, oral acute and 28 day toxicity studies were also carried out. Results: MS produced a dose dependent protective effect in all the experimental models. Its antiarthritic efficacy was comparable to aspirin in formaldehyde induced arthritis and was superior to aspirin in turpentine oil induced paw oedema and CFA induced arthritis. MS also inhibited the delayed increase in joint diameter as seen in control and aspirin treated animals in CFA induced arthritis. Oral LD50 of MS was found to be >5000 mg/kg in rats. Chronic administration did not produce any significant physiological changes in the tested animals. Interpretation & conclusions: Results of the present study suggest that the antiarthritic activity of MS was due to the interplay between its anti-inflammatory and disease modifying activities, thus supporting its use in traditional medicine for the treatment of RA.en_US
dc.identifier.citationSingh Surender, Nair Vinod, Gupta Y K. Antiarthritic activity of Majoon Suranjan (a polyherbal Unani formulation) in rat. Indian Journal of Medical Research. 2011 Sept; 134(3): 384-388.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/135772
dc.language.isoenen_US
dc.source.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193721/en_US
dc.subjectAdjuvant arthritisen_US
dc.subjectanalgesiaen_US
dc.subjectformaldehydeen_US
dc.subjectMajoon Suranjanen_US
dc.subjectpaw edemaen_US
dc.subjectturpentine oilen_US
dc.subject.meshAnalysis of Variance
dc.subject.meshAnimals
dc.subject.meshArthritis, Experimental --drug therapy
dc.subject.meshAspirin --administration & dosage
dc.subject.meshAspirin --pharmacology
dc.subject.meshDose-Response Relationship, Drug
dc.subject.meshFormaldehyde
dc.subject.meshMale
dc.subject.meshMedicine, Unani
dc.subject.meshPhytotherapy --methods
dc.subject.meshPlant Extracts --pharmacology
dc.subject.meshPlant Extracts --toxicity
dc.subject.meshRats
dc.subject.meshRats, Wistar
dc.subject.meshToxicity Tests
dc.subject.meshTurpentine
dc.titleAntiarthritic activity of Majoon Suranjan (a polyherbal Unani formulation) in rat.en_US
dc.typeArticleen_US
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