Influence of low and high doses of naloxone on tonic pain and motor activity in rats.

Simple item page
dc.contributor.authorMena, N Ben_US
dc.contributor.authorMathur, Ren_US
dc.contributor.authorNayar, Uen_US
dc.date.accessioned1996-10-01en_US
dc.date.accessioned2009-06-01T06:23:58Z
dc.date.available1996-10-01en_US
dc.date.available2009-06-01T06:23:58Z
dc.date.issued1996-10-01en_US
dc.description.abstractNaloxone has been reported to affect pain and locomotor activity differently depending on the dose. The objective of the present investigation was to study the effects of low and high (6 micrograms and 3 mg/kg, s.c.) doses of naloxone (Nx) on formalin-induced pain (tonic pain) and spontaneous motor activity and any correlation between them. The experiments were conducted on adult male Wistar rats. Tonic pain and spontaneous motor activity were recorded by the formalin test and video monitoring respectively. An increase in spontaneous motor activity (locomotion, movements and distance) was observed following formalin injection as compared to basal activity (P < 0.05). Low dose of Nx reduced the pain intensity and also the spontaneous motor activity during the later phase (after 15 min of formalin injection) (P < 0.05). High dose of Nx on the other hand increased the pain intensity but still reduced motor activity (P < 0.05). Both doses of Nx initially produced hyperalgesia (5 min peak). The bidirectional effects of Nx on formalin pain were dissociated from the spontaneous motor behavior of rats. A direct correlation could not be established between pain intensity and spontaneous motor activity.en_US
dc.description.affiliationDepartment of Physiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi.en_US
dc.identifier.citationMena NB, Mathur R, Nayar U. Influence of low and high doses of naloxone on tonic pain and motor activity in rats. Indian Journal of Physiology and Pharmacology. 1996 Oct; 40(4): 289-96en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/107356
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBehavior, Animal --drug effectsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshFormaldehydeen_US
dc.subject.meshMaleen_US
dc.subject.meshMotor Activity --drug effectsen_US
dc.subject.meshNaloxone --pharmacologyen_US
dc.subject.meshNarcotic Antagonists --pharmacologyen_US
dc.subject.meshNociceptors --drug effectsen_US
dc.subject.meshPain --chemically induceden_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.titleInfluence of low and high doses of naloxone on tonic pain and motor activity in rats.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Physiology and Pharmacology