Protective effect of pifithrin-alpha on brain ischemic reperfusion injury induced by bilateral common carotid arteries occlusion in gerbils.

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dc.contributor.authorGupta, Sen_US
dc.contributor.authorGupta, Y Ken_US
dc.contributor.authorSharma, S Sen_US
dc.date.accessioned2007-01-20en_US
dc.date.accessioned2009-06-01T07:14:36Z
dc.date.available2007-01-20en_US
dc.date.available2009-06-01T07:14:36Z
dc.date.issued2007-01-20en_US
dc.description.abstractInvolvement of p53 has been implicated in apoptosis induced cell death in ischemic reperfusion injury. In the present study, we have investigated neuroprotective potential of pifithrin-alpha, a p53 inhibitor in bilateral common carotid arteries occlusion (5 min) model of global cerebral ischemia in Mongolian gerbils. Gerbils were treated with pifithrin-alpha 3 mg/kg, ip. 30 min prior to occlusion. There was a significant increase in neurological symptoms and locomotor activity in ischemic animals as compared with the sham-operated animals. Increase in neurological symptoms and locomotor activity was attenuated by pifithrin-alpha 3 mg/ kg, ip. Significant increase in the number of the surviving neurons in the hippocampal CA1 pyramidal region was observed in ischemic animals treated with pifithrin-alpha 3 mg/kg, ip. This study demonstrates the neuroprotective effect of pifithrin-alpha in global cerebral ischemia in gerbils.en_US
dc.description.affiliationDepartment of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, S.A.S. Nagar, (Mohali) Punjab.en_US
dc.identifier.citationGupta S, Gupta YK, Sharma SS. Protective effect of pifithrin-alpha on brain ischemic reperfusion injury induced by bilateral common carotid arteries occlusion in gerbils. Indian Journal of Physiology and Pharmacology. 2007 Jan-Mar; 51(1): 62-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108006
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArterial Occlusive Diseases --complicationsen_US
dc.subject.meshBenzothiazoles --administration & dosageen_US
dc.subject.meshBrain Ischemia --etiologyen_US
dc.subject.meshCarotid Artery Diseases --complicationsen_US
dc.subject.meshCell Death --drug effectsen_US
dc.subject.meshCell Survival --drug effectsen_US
dc.subject.meshGerbillinaeen_US
dc.subject.meshHippocampus --drug effectsen_US
dc.subject.meshInjections, Intraperitonealen_US
dc.subject.meshMaleen_US
dc.subject.meshMotor Activity --drug effectsen_US
dc.subject.meshNeuroprotective Agents --administration & dosageen_US
dc.subject.meshPyramidal Cells --drug effectsen_US
dc.subject.meshReperfusion Injury --etiologyen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshToluene --administration & dosageen_US
dc.titleProtective effect of pifithrin-alpha on brain ischemic reperfusion injury induced by bilateral common carotid arteries occlusion in gerbils.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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