Evaluation of clinical, biochemical and hematological parameters in macrocytic anemia

Simple item page
dc.contributor.authorThimmappa, Nalinaen_US
dc.contributor.authorS. B., Vijethen_US
dc.contributor.authorG., Prashanthen_US
dc.contributor.authorB. K., Sreedevien_US
dc.date.accessioned2020-04-09T07:41:28Z
dc.date.available2020-04-09T07:41:28Z
dc.date.issued2019-03
dc.description.abstractBackground: Macrocytosis can be seen in many hematological and non-hematological disorders and more than one cause may co-exist in an individual. Serum vitamin B12 and folic acid tests are routinely ordered but they are limited by their low sensitivity and specificity. This study is done to analyze the clinical, hematological and biochemical parameters in macrocytic anemia and to study the difference between megaloblastic and non-megaloblastic anemia in these parameters.Methods: There were 100 patients presenting with macrocytosis were taken in to study. A detailed clinical history and physical examination was done in all cases. CBC, biochemical investigations, peripheral blood examination, Vitamin B12, folate levels, bone marrow aspiration and reticulocyte count was done in all cases.Results: Primary bone marrow disorders were the most common cause of macrocytosis (45%). The other causes in decreasing order of frequency were megaloblastic anemia (36%), alcoholism and liver disease (15%), drug induced (2%) and idiopathic thrombocytopenic purpura (1%). There was a significant difference in the mean values of MCV and serum LDH between megaloblastic and non-megaloblastic macrocytosis. When serum LDH >1124.5IU/L or MCV>120.5fl (criterion values of ROC curve) with reticulocyte count <2% was taken as criteria, the sensitivity was 94.4% and specificity was 93% for diagnosing megaloblastic anemia.Conclusions: Systematic evaluation of macrocytosis will help us to distinguish megaloblastic and non-megaloblastic macrocytosis. The blood and biochemical parameters especially CBC, RC, and serum LDH along with supporting clinical features help us in diagnosing megaloblastic anemia in a setup where vitamin and metabolite levels are difficult to obtain.en_US
dc.identifier.affiliationsDepartment of General Medicine, Basaveshwara Medical College and Hospital, Chitradurga, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of General Medicine, Basaveshwara Medical College and Hospital, Chitradurga, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of General Medicine, Basaveshwara Medical College and Hospital, Chitradurga, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of Community Medicine, Basaveshwara Medical College and Hospital, Chitradurga, Karnataka, Indiaen_US
dc.identifier.citationThimmappa Nalina, S. B. Vijeth, G. Prashanth, B. K. Sreedevi. Evaluation of clinical, biochemical and hematological parameters in macrocytic anemia. International Journal of Advances in Medicine. 2019 Mar; 6(2): 489-494en_US
dc.identifier.issn2349-3925
dc.identifier.issn2349-3933
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/194257
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber2en_US
dc.relation.volume6en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3933.ijam20191164en_US
dc.subjectAnemiaen_US
dc.subjectMacrocytosisen_US
dc.subjectMean corpuscular volumeen_US
dc.subjectMegaloblastic anemiaen_US
dc.subjectNon-megaloblastic macrocytosisen_US
dc.subjectSerum LDHen_US
dc.titleEvaluation of clinical, biochemical and hematological parameters in macrocytic anemiaen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijam2019v6n2p489.pdf
Size:
214.25 KB
Format:
Adobe Portable Document Format
Download
Collections
International Journal of Advances in Medicine