A clinicopathological and immunohistochemical study of malignant peripheral nerve sheath tumors.

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dc.contributor.authorSasidharan, Siny Vellukara
dc.contributor.authorKumar, Vinu
dc.contributor.authorPai, Radha R
dc.contributor.authorVasudevan, Sheela
dc.date.accessioned2015-11-10T06:11:45Z
dc.date.available2015-11-10T06:11:45Z
dc.date.issued2014-10
dc.description.abstractBackground: Malignant Peripheral Nerve Sheath Tumor (MPNST) is a rare aggressive sarcoma that develops within a peripheral nerve and forms a diagnostic challenge in view of its varied histomorphology. This short series highlights the clinicopathological spectrum of 11 cases of MPNST and the incidence of neurofibromatosis 1 (NF1) association. Methods: This retrospective and descriptive study on MPNST was done in the department of pathology, Kasturba medical college Mangalore (Manipal University), India over a period of three years from January 2008 to December 2010. Cases which were histopathologically diagnosed as MPNST were reviewed & immunostains was done where ever indicated to rule out the differentials. Results: A total of 11 cases of MPNST were documented with a wide age range of 17-85 years. Male:female ratio was 2.6:1. Extremities (63.64%) were found to be the most common site. Location wise most of the tumors were deep seated (63.64%) and maximum cases were high grade (54.55%). NF1 association was seen in 2 cases. Heterologous elements in the form of chondroid differentiation was seen in one case. Immunostain with S-100 was focally positive in all the cases. Conclusion: MPNST is a highly aggressive sarcoma with poor prognosis characterized by a challenge in its diagnosis as it has several mimics. Its diagnosis necessitates the incorporation of clinicopathological features and IHC with S-100 protein.en_US
dc.identifier.citationSasidharan Siny Vellukara, Kumar Vinu, Pai Radha R, Vasudevan Sheela. A clinicopathological and immunohistochemical study of malignant peripheral nerve sheath tumors. International Journal of Research in Medical Sciences. 2014 Oct-Dec; 2(4): 1307-1312.en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/165433
dc.language.isoenen_US
dc.source.urihttps://www.msjonline.org/?mno=164291en_US
dc.subjectMalignant peripheral nerve sheath tumoren_US
dc.subjectNeurofibromatosis (NF-1),en_US
dc.subjectHeterologous differentiationen_US
dc.titleA clinicopathological and immunohistochemical study of malignant peripheral nerve sheath tumors.en_US
dc.typeArticleen_US
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