A single-centre observational study of 124 surgically managed glioma patients: molecular subtyping and its correlation with clinico-radiological profile
dc.contributor.author | Singh, Ashutosh | en_US |
dc.contributor.author | Singh, Suyash | en_US |
dc.contributor.author | Agrawal, Sarita | en_US |
dc.contributor.author | Verma, Jyoti | en_US |
dc.contributor.author | Singh, Shalini | en_US |
dc.contributor.author | Misra, Prabhakar | en_US |
dc.contributor.author | Jaiswal, Awadhesh Kumar | en_US |
dc.contributor.author | Behari, Sanjay | en_US |
dc.contributor.author | Jaiswal, Sushila | en_US |
dc.date.accessioned | 2020-11-18T10:05:34Z | |
dc.date.available | 2020-11-18T10:05:34Z | |
dc.date.issued | 2020-09 | |
dc.description.abstract | Background: The World Health Organization (WHO) 2016 classification incorporated molecular subtyping in glioma, highlighting the diagnostic and prognostic significance. The study aims to determine the isocitrate dehydrogenase (IDH-1) gene, α-thalassemia/mental retardation syndrome X-linked (ATRX) gene, and tumor suppressor gene-53 (p53) mutation in glioma and their correlation with various clinical and radiological parameters.Methods: In this prospective observational study, histopathological slides of glioma (2017-2018), were analyzed for IDH-1, ATRX and p53 mutations and their correlation with various clinical and radiological parameters.Results: IDH-1 mutation was found in 48 (38.7%), ATRX loss in 38 (30.6%) and p53 mutation in 40 (32.5%) patients. The expression of IDH-1 was significantly higher (43.7%) in adults; however, no significant difference was seen with gender. Also 51.2% of patients, who presented with seizures, showed IDH-1 expression; and 27.7% of patients, who had neurological deficit also showed IDH-1 expression. IDH-1 expression was high in glioma located at insula (73.3%) and parietal lobe (71.4%); while ATRX loss was seen in glioma located at insula (80%). Intraventricular glioma characteristically lacks all three markers: IDH-1 expression, p53 overexpression and ATRX loss. IDH-1 expression and p53 overexpression was seen mainly in diffuse fibrillary astrocytoma, oligodendroglioma, anaplastic astrocytoma and glioblastoma.Conclusions: Molecular subtyping is of paramount importance in glioma management. IDH-1 mutation is commonly observed in adults and patients presenting with seizures. The duration of symptoms correlates with IDH-1 and ATRX mutations. Hypothalamic tumors lack all three mutations. | en_US |
dc.identifier.affiliations | Department of Pathology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India | en_US |
dc.identifier.affiliations | Department of Neurosurgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India | en_US |
dc.identifier.affiliations | Department of Medical Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India | en_US |
dc.identifier.affiliations | Department of Radiotherapy, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India | en_US |
dc.identifier.affiliations | Department of Biostatistics and Health Informatics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India | en_US |
dc.identifier.citation | Singh Ashutosh, Singh Suyash, Agrawal Sarita, Verma Jyoti, Singh Shalini, Misra Prabhakar, Jaiswal Awadhesh Kumar, Behari Sanjay, Jaiswal Sushila. A single-centre observational study of 124 surgically managed glioma patients: molecular subtyping and its correlation with clinico-radiological profile. International Surgery Journal. 2020 Sep; 7(9): 3047-3055 | en_US |
dc.identifier.issn | 2349-3305 | |
dc.identifier.issn | 2349-2902 | |
dc.identifier.place | India | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/213326 | |
dc.language | en | en_US |
dc.publisher | Medip Academy | en_US |
dc.relation.issuenumber | 9 | en_US |
dc.relation.volume | 7 | en_US |
dc.source.uri | https://dx.doi.org/10.18203/2349-2902.isj20203792 | en_US |
dc.subject | Isocitrate dehydrogenase-1 mutation | en_US |
dc.subject | Glioma | en_US |
dc.subject | Immunohistochemistry | en_US |
dc.subject | α-thalassemia/mental retardation syndrome X-linked gene | en_US |
dc.subject | Tumor suppressor gene-53 | en_US |
dc.subject | Astrocytic tumors | en_US |
dc.title | A single-centre observational study of 124 surgically managed glioma patients: molecular subtyping and its correlation with clinico-radiological profile | en_US |
dc.type | Journal Article | en_US |
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