Levetiracetam versus phenytoin for treatment of convulsive status epilepticus in pediatric population: a randomized controlled trial

Simple item page
dc.contributor.authorSharma, Poojaen_US
dc.contributor.authorMandot, Sanjayen_US
dc.contributor.authorBamnawat, Subhashen_US
dc.date.accessioned2020-09-24T07:43:19Z
dc.date.available2020-09-24T07:43:19Z
dc.date.issued2019-03
dc.description.abstractBackground: Status epilepticus is a major medical and neurological emergency. Despite advances in treatment, it is still associated with significant morbidity and mortality. The objective of the study was to compare the efficacy of levetiracetam versus phenytoin in treatment of convulsive status epilepticus.Methods: A Randomized control trial, was conducted at tertiary care hospital, Udaipur, Rajasthan, over a period of March 2017 to September 2018. Total 250 patients (age group 6 months to 18 years) who were presented with status epilepticus in PICU, were enrolled. These patients were divided into two groups by simple randomization. Levetiracetam was given to one group, while phenytoin was given to another group. Efficacy was decided by cessation of clinical seizure activity within 30 minutes of starting of drug infusion and patient was observed for recurrence of seizure within 24 hours.Results: A total of 250 patients were enrolled in this study. Seizure terminated in 107 patients in phenytoin group (85.6%) and in 114 patients in levetiracetam group (91.2%). The difference was significant. Recurrence of seizure (with in 24 hour) was high in phenytoin group (14.4%) in comparison with levetiracetam group (8.8%). Most common adverse effect in both the groups on treatment was hypotension, though in phenytoin group it was significantly higher than patients on levetiracetam group (7.2% v/v 2.4%).Conclusions: Levetiracetam may be an effective alternative to phenytoin as a second line drug in the management of benzodiazepine resistant convulsive status epilepticus in children.en_US
dc.identifier.affiliationsDepartment of Pediatrics, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, Indiaen_US
dc.identifier.citationSharma Pooja, Mandot Sanjay, Bamnawat Subhash. Levetiracetam versus phenytoin for treatment of convulsive status epilepticus in pediatric population: a randomized controlled trial. International Journal of Contemporary Pediatrics. 2019 Mar; 6(2): 741-745en_US
dc.identifier.issn2349-3283
dc.identifier.issn2349-3291
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/204014
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber2en_US
dc.relation.volume6en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3291.ijcp20190722en_US
dc.subjectLevetiracetamen_US
dc.subjectPhenytoinen_US
dc.subjectSeizureen_US
dc.subjectStatus epilepticusen_US
dc.titleLevetiracetam versus phenytoin for treatment of convulsive status epilepticus in pediatric population: a randomized controlled trialen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijcp2019v6n2p741.pdf
Size:
187.03 KB
Format:
Adobe Portable Document Format
Download
Collections
International Journal of Contemporary Pediatrics