Understand the risk factors associated with non alcoholic fatty liver disease and changes in biochemical parameters in the patients: a prospective study

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dc.contributor.authorShende, Atulen_US
dc.contributor.authorChandra, Umesh Kumaren_US
dc.contributor.authorGowda, Dharshanen_US
dc.contributor.authorWarkade, Vinayen_US
dc.contributor.authorGanganpalli, Dattaprasaden_US
dc.date.accessioned2020-04-09T07:43:54Z
dc.date.available2020-04-09T07:43:54Z
dc.date.issued2020-03
dc.description.abstractBackground: The true prevalence of both NAFLD and NASH are elusive but estimates based on imaging and autopsy studies suggest that about 20-30% of the adults in United States and western countries have excess fat accumulation in the liver. About 10% of these, strictly speaking about 2-3% of the adult population fulfils the criteria of NASH. True prevalence of NAFLD in Indian patients is not known. So, this study was planned to look for current trend of NAFLD in Indian patients.Methods: This prospective observational study was conducted in the Department of Medicine on 65 patients with ultra-sonography finding of fatty liver disease with no history of alcohol, in one year study duration.Results: It is observed that maximum patients are of middle age from age 31-60 years comprising 76% of patients. Out of total patients, 34% and 66% were males and females respectively. Out of 65 patients, 45(69%) had obesity and maximum number of the patients had waist hip ratio and neck circumference more than the cut off value. Out of 65 patients, 19(29%) had hypercholesterolemia and 42(65%) had hyper-triglyceridemia. Out of 65 patients, 32(49%) had higher alanine transaminase (ALT) level and 17(29%) patients had higher AST level. Out of 65 patients, 29(45%) had the homeostasis model assessment of insulin resistance (HOMA-IR) less than cut off value (less than 2.25) and remaining 36(55%) were having HOMA-IR more than 2.25. The sensitivity for the cut off value for HOMA-IR is 72.7% and specificity is 49.1%.Conclusions: Obesity, neck circumference, and waist hip ratio are higher than its cut off value for both sex, insulin resistance evaluated through HOMA- IR directly relates to the causation of NAFLD but at some extents higher triglyceride levels are also associated but the values of ALT and AST levels did not give any clue in these cases of NAFLD.en_US
dc.identifier.affiliationsDepartment of Medicine, MGM Medical College and MY Hospital, Indore, Madhya Pradesh, Indiaen_US
dc.identifier.citationShende Atul, Chandra Umesh Kumar, Gowda Dharshan, Warkade Vinay, Ganganpalli Dattaprasad. Understand the risk factors associated with non alcoholic fatty liver disease and changes in biochemical parameters in the patients: a prospective study. International Journal of Advances in Medicine. 2020 Mar; 7(3): 517-522en_US
dc.identifier.issn2349-3925
dc.identifier.issn2349-3933
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/194627
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber3en_US
dc.relation.volume7en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3933.ijam20200668en_US
dc.subjectAlanine transaminaseen_US
dc.subjectCholesterolen_US
dc.subjectHomeostasis model assessment of insulin resistanceen_US
dc.subjectNon alcoholic fatty liver diseaseen_US
dc.subjectNon alcoholic steatohepatitisen_US
dc.subjectTriglycerideen_US
dc.titleUnderstand the risk factors associated with non alcoholic fatty liver disease and changes in biochemical parameters in the patients: a prospective studyen_US
dc.typeJournal Articleen_US
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