Insulin-like growth factors-I and -II and insulin-like growth factor binding protein-1 during normal pregnancy: pattern of secretion and correlation with other placental hormones.

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dc.contributor.authorTennekoon, K Hen_US
dc.contributor.authorPathmaperuma, A Nen_US
dc.contributor.authorSenanayake, Len_US
dc.contributor.authorKarunanayake, E Hen_US
dc.date.accessioned2009-05-28T05:32:23Z
dc.date.available2009-05-28T05:32:23Z
dc.date.issued2007-03-26en_US
dc.descriptionThe Ceylon Medical Journal.en_US
dc.description.abstractOBJECTIVES: To describe pattern of secretion of insulin-like growth factor (IGF)-I, IGF-II, IGF binding protein (IGFBP)-1 and their correlation with each other and major placental hormones during normal pregnancy. DESIGN: Longitudinal study. SETTING: Academic Institutions and a Tertiary Care Maternity Hospital. PARTICIPANTS: Healthy women with singleton uncomplicated pregnancies (N = 35). MEASUREMENTS: Serum levels of IGF-I, IGF-II, IGFBP-1, chorionic gonadotrophin (HCG), placental lactogen (HPL), prolactin, oestradiol and progesterone were studied thrice during the antenatal period and within 24 h of delivery. RESULTS: IGF-I, IGFBP-1, HPL, prolactin, oestradiol and progesterone increased and HCG decreased significantly with advancing gestation (Repeated measures ANOVA: P < 0.01 to 0.0001). IGF-II levels were not significantly affected by period of gestation. Significant negative correlations (multiple regression analysis) were seen between IGFBP-1 and prolactin at 28 +/- 2 (P = 0.0226) and 36 +/- 2 (P = 0.0417) weeks of amenorrhoea (WOA) and between oestradiol and IGF-II at 36 +/- 2 WOA (P = 0.037). Prolactin and IGF-I at 14 +/- 2 WOA (P = 0.0225) and progesterone and IGFBP-1 at 28 +/- 2 WOA (P = 0.0216) correlated positively. CONCLUSIONS: Maternal IGF-I and IGFBP-1 but not IGF-II significantly increase as pregnancy advances. Components of the IGF system regulate or are affected by some of the placental hormones and the effects vary with the period of gestation.en_US
dc.description.affiliationDepartment of Physiology, Faculty of Medicine, University of Colombo. khtennekoon@med.cmb.ac.lken_US
dc.identifier.citationTennekoon KH, Pathmaperuma AN, Senanayake L, Karunanayake EH. Insulin-like growth factors-I and -II and insulin-like growth factor binding protein-1 during normal pregnancy: pattern of secretion and correlation with other placental hormones. The Ceylon Medical Journal. 2007 Mar; 52(1): 8-13en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/48638
dc.language.isoengen_US
dc.source.urihttps://www.infolanka.com/CMJhome/en_US
dc.source.urihttps://www.sljol.info/index.php/CMJ/article/view/1038/966en_US
dc.subject.meshAdulten_US
dc.subject.meshChorionic Gonadotropin --blooden_US
dc.subject.meshEstradiol --blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInsulin-Like Growth Factor Binding Protein 1 --blooden_US
dc.subject.meshInsulin-Like Growth Factor I --secretionen_US
dc.subject.meshInsulin-Like Growth Factor II --secretionen_US
dc.subject.meshPlacenta --metabolismen_US
dc.subject.meshPlacental Lactogen --blooden_US
dc.subject.meshPregnancy --metabolismen_US
dc.subject.meshProgesterone --secretionen_US
dc.subject.meshProlactin --blooden_US
dc.titleInsulin-like growth factors-I and -II and insulin-like growth factor binding protein-1 during normal pregnancy: pattern of secretion and correlation with other placental hormones.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
dc.typeResearch Support, U.S. Gov't, Non-P.H.S.en_US
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