Preoperative ephedrine counters hypotension with propofol anesthesia during valve surgery: A dose dependent study.

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dc.contributor.authorEl-Tahan, Mohamed R
dc.date.accessioned2012-07-17T04:45:08Z
dc.date.available2012-07-17T04:45:08Z
dc.date.issued2011-01
dc.description.abstractThe prophylactic use of small doses of ephedrine may counter the hypotension response to propofol anesthesia with minimal hemodynamic changes. One hundred-fifty patients scheduled for valve surgery were randomly assigned into five groups (n = 30 for each) to receive saline, 0.07, 0.1, or 0.15 mg/kg of ephedrine, or phenylephrine 1.5 μg/kg before induction of propofol-fentanyl anesthesia. After induction, patient receiving ephedrine had higher mean arterial pressure, systemic vascular resistance (SVRI), cardiac (CI), stroke volume (SVI), and left ventricular stroke work (LVSWI) indices. Patients received 0.15 mg/kg of ephedrine showed additional increased heart rate and frequent ischemic episodes (P < 0.001). However, those who received phenylephrine showed greater rise in SVRI, reduced CI, SVI, and LVSWI and more frequent ischemic episodes. We conclude that the prophylactic use of small doses of ephedrine (0.07−0.1 mg/kg) is safe and effective in the counteracting propofol-induced hypotension during anesthesia for valve surgery.en_US
dc.identifier.citationEl-Tahan Mohamed R. Preoperative ephedrine counters hypotension with propofol anesthesia during valve surgery: A dose dependent study. Annals of Cardiac Anaesthesia. 2011 Jan; 14(1): 30-40.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/139559
dc.language.isoenen_US
dc.source.urihttps://www.annals.in/article.asp?issn=0971-9784;year=2011;volume=14;issue=1;spage=30;epage=40;aulast=El-Tahanen_US
dc.subjectCardiac anesthesiaen_US
dc.subjectephedrineen_US
dc.subjecthypotensionen_US
dc.subjectphenylephrineen_US
dc.subjectpropofolen_US
dc.subject.meshAdult
dc.subject.meshAnesthetics, Intravenous --adverse effects
dc.subject.meshDose-Response Relationship, Drug
dc.subject.meshDouble-Blind Method
dc.subject.meshEphedrine --therapeutic use
dc.subject.meshFemale
dc.subject.meshHeart Valves --surgery
dc.subject.meshHemodynamics --drug effects
dc.subject.meshHumans
dc.subject.meshHypotension --prevention & control
dc.subject.meshLogistic Models
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPropofol --adverse effects
dc.subject.meshRheumatic Heart Disease --surgery
dc.titlePreoperative ephedrine counters hypotension with propofol anesthesia during valve surgery: A dose dependent study.en_US
dc.typeArticleen_US
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