Two novel antimicrobial and anticancer peptides prediction from Vibrio sp. strain ES25

Simple item page
dc.contributor.authorSugrani, Andisen_US
dc.contributor.authorAhmad, Ahyaren_US
dc.contributor.authorDjide, Muhammad Natsiren_US
dc.contributor.authorNatsir, Hasnahen_US
dc.date.accessioned2020-10-16T08:56:39Z
dc.date.available2020-10-16T08:56:39Z
dc.date.issued2020-08
dc.description.abstractProteins from microbes are a large source of potential raw material for novel pharmaceuticals. Endophytic bacteriaassociated with algae associated have been shown to be particularly promising candidates. In a previous study, a crudeprotein extract was isolated from an endophytic Vibrio sp. strain ES25. The extract was found to have anti-microbialactivity. Despite these promising results, further work was needed to characterize both the protein and the bacteria thatproduce it. In this study, we sought to increase the activity of the previously discovered protein through pepsin digestionas well as provide sequence data to characterize the bacterial isolate. Here, we show promising evidence that thehydrolysate produced (QA1d) was found to have a promising antimicrobial as well as anticancer properties. Through theDNA sequencing, we also provide better taxonomic information on the isolate. Finally using Liquid ChromatographyMass Spectroscopy/Mass Spectroscopy (LC-MS/MS) and in silico prediction, we identify to novel peptides producedfrom the bacterial protein that were predicted to have multifunctional activity. These results shown here indicate thesepeptides are promising candidates for anticancer drug development or antibacterial agents for the food industry.en_US
dc.identifier.affiliationsDepartment of Medical Laboratory Technology, Megarezky University of Makassar, Makassar, Indonesiaen_US
dc.identifier.affiliationsChemistry Department, Mathematic and Natural Science Faculty, Hasanuddin University, Makassar, Indonesiaen_US
dc.identifier.affiliationsFaculty of Pharmacy, Hasanuddin University, Makassar, Indonesiaen_US
dc.identifier.affiliationsDepartment of Medical Laboratory Technology, Megarezky University of Makassar, Makassar, Indonesiaen_US
dc.identifier.citationSugrani Andis, Ahmad Ahyar, Djide Muhammad Natsir, Natsir Hasnah. Two novel antimicrobial and anticancer peptides prediction from Vibrio sp. strain ES25. Journal of Applied Pharmaceutical Science. 2020 Aug; 2020 Aug: 058-066en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/210643
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber8en_US
dc.relation.volume10en_US
dc.source.urihttps://dx.doi.org//10.7324/JAPS.2020.10807en_US
dc.subjectAntibacterialen_US
dc.subjectanticanceren_US
dc.subjectendophytic bacteriaen_US
dc.subjectpeptideen_US
dc.subjectproteinen_US
dc.subjectprotein hydrolysateen_US
dc.subjectVibrio.en_US
dc.titleTwo novel antimicrobial and anticancer peptides prediction from Vibrio sp. strain ES25en_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
japs2020v10n8p058.pdf
Size:
1.8 MB
Format:
Adobe Portable Document Format
Download
Collections
Journal of Applied Pharmaceutical Science (JAPS)