Evidence for activation of cellular immune responses in patients with acute hepatitis E.

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dc.contributor.authorNaik, Sitaen_US
dc.contributor.authorAggarwal, Rakeshen_US
dc.contributor.authorNaik, Subhash Ren_US
dc.contributor.authorDwivedi, Sunitaen_US
dc.contributor.authorTalwar, Sudhaen_US
dc.contributor.authorTyagi, S Ken_US
dc.contributor.authorDuhan, S Den_US
dc.contributor.authorCoursaget, Pen_US
dc.date.accessioned2002-07-19en_US
dc.date.accessioned2009-05-29T03:04:24Z
dc.date.available2002-07-19en_US
dc.date.available2009-05-29T03:04:24Z
dc.date.issued2002-07-19en_US
dc.description.abstractINTRODUCTION: Although acute hepatitis E virus (HEV) infection is known to induce IgM and IgG humoral host immune responses, little is known about occurrence of cellular responses in this infection. We looked for evidence of lymphocyte sensitization to HEV peptides in patients with acute HEV infection. METHODS: peripheral blood lymphocytes were obtained from patients with acute hepatitis E and healthy controls. Proliferation of these lymphocytes in the presence of each of seven peptides with amino acid sequences corresponding to open reading frames 2 and 3 proteins of HEV (3 and 4 peptides, respectively) were studied; no peptide was added to control wells. Proliferative responses with stimulation indices exceeding 3.0 were taken as positive. RESULTS: More patients showed reactivity to two or more HEV peptides than did controls (11/21 vs 5/22, p<0.05). Reactivity to one peptide corresponding to open reading frame 2 of HEV was more frequent in patients than in controls (7/21 vs 1/22, p<0.05). CONCLUSION: Our results show that lymphocytes of patients with acute hepatitis E show sensitization to HEV peptides. This may have significance in understanding the pathogenetic mechanisms of liver injury in this infection.en_US
dc.description.affiliationDepartment of Immunology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow. sitanaik@sgpgi.ac.inen_US
dc.identifier.citationNaik S, Aggarwal R, Naik SR, Dwivedi S, Talwar S, Tyagi SK, Duhan SD, Coursaget P. Evidence for activation of cellular immune responses in patients with acute hepatitis E. Indian Journal of Gastroenterology. 2002 Jul-Aug; 21(4): 149-52en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/64901
dc.language.isoengen_US
dc.source.urihttps://www.indianjgastro.comen_US
dc.subject.meshAcute Diseaseen_US
dc.subject.meshAdulten_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatitis E --immunologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunity, Cellularen_US
dc.subject.meshLeukocytes, Mononuclear --immunologyen_US
dc.subject.meshLymphocytes --immunologyen_US
dc.subject.meshMaleen_US
dc.titleEvidence for activation of cellular immune responses in patients with acute hepatitis E.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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