In Vitro Evaluation of the Antimicrobial and Antimycobacterial Activities of Solanum guaraniticum A. St.-Hil. Leaves.

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dc.contributor.authorZadra, Marina
dc.contributor.authorPiana, Mariana
dc.contributor.authorBoligon, Aline Augusti
dc.contributor.authorBrum, Thiele Faccim De
dc.contributor.authorRossato, Luana
dc.contributor.authorAlves, Sydney Hartz
dc.contributor.authorDalmolin, Tanise Vendruscolo
dc.contributor.authorCampos, Marli Matiko Anraku De
dc.contributor.authorAthayde, Margareth Linde
dc.date.accessioned2014-06-09T11:03:20Z
dc.date.available2014-06-09T11:03:20Z
dc.date.issued2013-09
dc.description.abstractWith the emergence of antimicrobial resistance, it becomes necessary to search for new alternatives for the treatment of infectious diseases. Solanum guaraniticum is a shrub known as jurubeba or false jurubeba that has hepatoprotective and antioxidant activities, used in popular medicine for the treatment of various diseases. The aim of this study was to evaluate the in vitro antimicrobial and antimycobacterial activities of crude extract, chloroforn, ethyl acetate and butanol fractions from its leaves. Good activities were observed for the ethyl acetate fraction against Staphylococcus intermedius and Listeria monocytogenes (MIC = 64 μg/mL) and for the crude extract against Micrococcus luteus (MIC = 32 μg/mL). In general, the extracts showed moderate activity against Gram-positive bacteria, and were inactive against Gram-negative bacteria and fungi. It was also verified considerable activity against Mycobacterium smegmatis, mainly by chloroform fraction (MIC = 156 μg/mL). These results are probably due to the good antioxidant activity and to the presence of high contents of polyphenols, tannins and alkaloids, metabolites known to possess antimicrobial activity. Studies aiming the isolation of compounds are necessary in order to know the main component involved in these activities, since the plant has an antimicrobial potential.en_US
dc.identifier.citationZadra Marina, Piana Mariana, Boligon Aline Augusti, Brum Thiele Faccim De, Rossato Luana, Alves Sydney Hartz, Dalmolin Tanise Vendruscolo, Campos Marli Matiko Anraku De, Athayde Margareth Linde. In Vitro Evaluation of the Antimicrobial and Antimycobacterial Activities of Solanum guaraniticum A. St.-Hil. Leaves. Journal of Applied Pharmaceutical Science. 2013 Sept; 3(9): 19-23.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/151854
dc.language.isoenen_US
dc.source.urihttps://www.japsonline.com/counter.php?aid=1042en_US
dc.subjectAntimicrobialen_US
dc.subjectantimycobacterialen_US
dc.subjectjurubebaen_US
dc.subjectpolyphenolsen_US
dc.subjectS. guaraniticum.en_US
dc.titleIn Vitro Evaluation of the Antimicrobial and Antimycobacterial Activities of Solanum guaraniticum A. St.-Hil. Leaves.en_US
dc.typeArticleen_US
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