Antiatherogenic effect of a low lysine: arginine ratio of protein involves alteration in the aortic glycosamihoglycans and glycoproteins.
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Date
1990-12
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Abstract
The effect of alteration of lysine: arginine ratio of the protein on the aortic
glycosaminoglycans and glycoproteins was studied in rats fed cholesterol free and
atherogenic diet. The concentration of total glycosaminoglycans and of individual fractions
was significantly lower in the aorta in the case of diet with lysine: arginine ratio of 1·0,
than the diet with a ratio of 2·0. Rats fed globulin fraction isolated from sesame seeds,
which has a lysine: arginine ratio of 0·67 also showed significantly lower concentration of
total and individual glycosaminoglycan fractions in the aorta than those fed casein
(lysine:arginine ratio 2·0). Concentration of total hexose and fucose in the glycoproteins
was also lower in the aorta in the case of lysine: arginine ratio 1·0. These results in the light
of previous reports of increase in the aortic glycosaminoglycans in the early stages of
atherosclerosis and increase in the total hexose and fucose in the glycoproteins in the
atherosclerotic aorta indicate that the antiatherogenic effect of a low lysine: arginine ratio
in the protein involves alteration in the aortic glycosaminoglycans and glycoproteins.
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Keywords
Lysine, arginine ratio, glycosaminoglycans, glycoproteins
Citation
Rajamohan T, Kurup P A. Antiatherogenic effect of a low lysine: arginine ratio of protein involves alteration in the aortic glycosamihoglycans and glycoproteins. Journal of Biosciences. 1990 Dec; 15(4): 305-311.