Effect of liver disease on maternal and fetal outcome--a prospective study.

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dc.contributor.authorRathi, Umangen_US
dc.contributor.authorBapat, Muktaen_US
dc.contributor.authorRathi, Pravinen_US
dc.contributor.authorAbraham, Philipen_US
dc.date.accessioned2007-03-15en_US
dc.date.accessioned2009-05-29T02:47:53Z
dc.date.available2007-03-15en_US
dc.date.available2009-05-29T02:47:53Z
dc.date.issued2007-03-15en_US
dc.description.abstractBACKGROUND: Liver disease in pregnancy can have serious consequences. Its prevalence, profile and effect on outcome of pregnancy have not been documented systematically in India. We prospectively determined the frequency, causes and outcome of liver disease in pregnant women. SETTING: Tertiary-care teaching hospital. METHODS: Consecutive pregnant women with liver disease attending the inpatient or outpatient services of the Departments of Gastro-enterology and Obstetrics and Gynecology between December 2002 and October 2004 were evaluated and followed up till 2 weeks postpartum or death. RESULTS: Liver disease was found in 107 (0.9%) of 12,061 pregnancies. Of these, fifty six (52.3%) had pregnancy-specific liver disorders (pregnancy-induced hypertension [PIH]-associated liver dysfunction 36--including HELLP syndrome 22 and pre-eclamptic liver dysfunction 14; intrahepatic cholestasis of pregnancy 10; hyperemesis gravidarum 7; acute fatty liver of pregnancy 3). Liver disorders not specific to pregnancy included hepatitis E (16), hepatitis B, non A-E hepatitis and chronic liver disease (5 each) and others (14); in 6 patients no cause could be found. Ninety-six patients completed follow up. Overall maternal and perinatal mortality rates were 19.7% and 35.4%, respectively. CONCLUSIONS: PIH-associated liver dysfunction was the most common cause of liver disease in pregnancy. This is associated with significant maternal and perinatal morbidity and mortality.en_US
dc.description.affiliationDepartment of Gastroenterology, Seth G S Medical College and King Edward Memorial Hospital, Mumbai 400 012, India.en_US
dc.identifier.citationRathi U, Bapat M, Rathi P, Abraham P. Effect of liver disease on maternal and fetal outcome--a prospective study. Indian Journal of Gastroenterology. 2007 Mar-Apr; 26(2): 59-63en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/64571
dc.language.isoengen_US
dc.source.urihttps://www.indianjgastro.comen_US
dc.subject.meshFemaleen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshInfant Mortalityen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshLiver Diseases --diagnosisen_US
dc.subject.meshMaternal Mortalityen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPregnancy Complications --diagnosisen_US
dc.subject.meshPregnancy Outcome --epidemiologyen_US
dc.subject.meshProspective Studiesen_US
dc.titleEffect of liver disease on maternal and fetal outcome--a prospective study.en_US
dc.typeJournal Articleen_US
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