Anticonvulsant property of celecoxib in maximal electroshock seizure: Correlating the role of inflammation in pathophysiology of epileptic seizures

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dc.contributor.authorJain, Ren_US
dc.contributor.authorKhare, Nen_US
dc.contributor.authorJain, A.en_US
dc.date.accessioned2023-06-27T06:41:33Z
dc.date.available2023-06-27T06:41:33Z
dc.date.issued2023-02
dc.description.abstractBackground: Epilepsy is an abnormal excessive electric neuronal activity and always represents by recurrent seizures. There is positive feedback cycle between epileptogenesis and brain inflammation. It has been proved that an inflammatory enzyme, cyclooxygenase (COX) (especially isoform-2, a constitutive enzyme), expressed in some important parts of the central nervous system and is responsible to induced inflammation locally and having seizurogenic property. Aim and Objective: The goal of this study was to see if celecoxib (a selective COX-2 inhibitor) could reduce the maximal electroshock seizure (MES)-induced seizures in mice. Materials and Methods: Celecoxib injected intraperitoneally in two different doses 5 mg/kgb/w and 10 mg/kg b/w, in albino Swiss mice and in two different phases. MES was elicited and length of different phases was noted. Length of tonic hindlimb extension was considered as indicator of anti-epileptic activity. Results: Celecoxib, when given intraperitoneally, exert significant reduction in the duration of THLE. This action of celecoxib strongly suggests the involvement of inflammation in the pathophysiology of epilepsy. Conclusion: The findings are suggestive of the therapeutic significance of celecoxib, as a future antiepileptic agent for seizure management.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Atal Bihari Vajpayee Government Medical College, Vidisha, Madhya Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Preventive and Social Medicine, Atal Bihari Vajpayee Government Medical College, Vidisha, Madhya Pradesh, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, People’s College of Medical Sciences and Research Centre, Bhopal, Madhya Pradesh, Indiaen_US
dc.identifier.citationJain R, Khare N, Jain A.. Anticonvulsant property of celecoxib in maximal electroshock seizure: Correlating the role of inflammation in pathophysiology of epileptic seizures. National Journal of Physiology, Pharmacy and Pharmacology. 2023 Feb; 13(2): 282-285en_US
dc.identifier.issn2231-3206
dc.identifier.issn2320-4672
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/217909
dc.languageenen_US
dc.publisherMrs Dipika Charan of MedScience (India) Publicationsen_US
dc.relation.issuenumber2en_US
dc.relation.volume13en_US
dc.source.urihttps://dx.doi.org/10.5455/njppp.2023.13.05203202222062022en_US
dc.subjectEpilepsyen_US
dc.subjectInflammationen_US
dc.subjectCyclooxygenase-2 Inhibitorsen_US
dc.subjectCelecoxiben_US
dc.subjectMaximal Electroshock Seizureen_US
dc.subjectTHLEen_US
dc.titleAnticonvulsant property of celecoxib in maximal electroshock seizure: Correlating the role of inflammation in pathophysiology of epileptic seizuresen_US
dc.typeJournal Articleen_US
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