Demographic and Clinical Profile of Patients Presenting with COVID-19-Associated Rhino-orbito-cerebral Mucormycosis at a Tertiary Care Center

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dc.contributor.authorMadan, Siddharthen_US
dc.contributor.authorYadav, Rekhaen_US
dc.contributor.authorRohatgi, Jollyen_US
dc.contributor.authorSharma, Rahulen_US
dc.contributor.authorNasir, Iffaten_US
dc.contributor.authorSaini, Aarushien_US
dc.contributor.authorTadu, Nampien_US
dc.contributor.authorDas, Gopal Krushnaen_US
dc.contributor.authorSahu, Pramod Kumaren_US
dc.contributor.authorGupta, Neelimaen_US
dc.contributor.authorBeri, Nitikaen_US
dc.date.accessioned2023-07-21T11:27:57Z
dc.date.available2023-07-21T11:27:57Z
dc.date.issued2022-10
dc.description.abstractObjectives?Individuals affected with rhino-orbito-cerebral mucormycosis (ROCM) associated with coronavirus disease 2019 (COVID-19) increased enormously in northern India during the second wave of the novel coronavirus disease. This study determined the demographic and clinical profile including the risk factors in patients presenting to a tertiary care hospital in northern India. Materials and Methods?This is a descriptive study involving patients admitted with COVID-19-associated ROCM and were managed from May 2021 to 20th July 2021. Statistical Analysis?The data was analyzed using SPSS (IBM SPSS Statistics 20, SPSS Inc., Chicago, Illinois, United States) software and Microsoft Excel (Version 16.49). The chi-squared and Fisher's exact tests were used to compare various outcomes. A p-value of less than or equal to 0.05 was considered to be statistically significant. Results?One hundred and seventeen (117) patients (males: 70 [59.8%], females:47 [40.2%]) with the average age of 51.85?±?12.80 years presented with orbital involvement. Diabetes mellitus was noted in 100 (86.2%) patients. Of the available data from the records, oxygen supplementation for the management of COVID-19 was received by 37/108 (34.3%) patients for a median average duration of 11 days. Forty-eight patients of one-hundred-seventeen (60%) patients were treated with corticosteroids with a median duration of steroid administration being 10 days. The duration between onset of symptoms related to mucormycosis and diagnosis of COVID-19 was 0 to 75 days for 48 patients. Intravenous amphotericin B was administered in all cases. External sinonasal debridement was performed in 90 of 114 (78.9%) patients, retrobulbar amphotericin B injection was administered in 56 of 117 (47.9%), and orbital exenteration was performed in 17 of 117 (14.5%) of cases. Conclusion?Administration of corticosteroids and diabetes mellitus seem to be the major underlying causes for the development of COVID-19-associated ROCM. Prompt diagnosis and multidisciplinary management approach are essential for a reduction in mortality.en_US
dc.identifier.affiliationsDepartment of Ophthalmology, University College of Medical Sciences and Associated GTB Hospital, University of Delhi, Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Ophthalmology, University College of Medical Sciences and Associated GTB Hospital, University of Delhi, Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Ophthalmology, University College of Medical Sciences and Associated GTB Hospital, University of Delhi, Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Community Medicine, University College of Medical Sciences and Associated GTB Hospital, University of Delhi, Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Ophthalmology, University College of Medical Sciences and Associated GTB Hospital, University of Delhi, Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Ophthalmology, University College of Medical Sciences and Associated GTB Hospital, University of Delhi, Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Ophthalmology, University College of Medical Sciences and Associated GTB Hospital, University of Delhi, Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Ophthalmology, University College of Medical Sciences and Associated GTB Hospital, University of Delhi, Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Ophthalmology, University College of Medical Sciences and Associated GTB Hospital, University of Delhi, Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of ENT, University College of Medical Sciences and Associated GTB Hospital, University of Delhi, Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Ophthalmology, University College of Medical Sciences and Associated GTB Hospital, University of Delhi, Delhi, Indiaen_US
dc.identifier.citationMadan, Siddharthen_US
dc.identifier.citationYadav, Rekhaen_US
dc.identifier.citationRohatgi, Jollyen_US
dc.identifier.citationSharma, Rahulen_US
dc.identifier.citationNasir, Iffaten_US
dc.identifier.citationSaini, Aarushien_US
dc.identifier.citationTadu, Nampien_US
dc.identifier.citationDas, Gopal Krushnaen_US
dc.identifier.citationSahu, Pramod Kumaren_US
dc.identifier.citationGupta, Neelimaen_US
dc.identifier.citationBeri, Nitika. Demographic and Clinical Profile of Patients Presenting with COVID-19-Associated Rhino-orbito-cerebral Mucormycosis at a Tertiary Care Center. Annals of the National Academy of Medical Sciences. 2022 Oct; 58(4): 210-219en_US
dc.identifier.issn0379-038X
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/220199
dc.languageenen_US
dc.publisherThieme Medical and Scientific Publishers Pvt. Ltden_US
dc.relation.issuenumber4en_US
dc.relation.volume58en_US
dc.source.urihttps://doi.org/10.1055/s-0042-1757894en_US
dc.subjectROCMen_US
dc.subjectCOVID-19en_US
dc.subjectorbital mucormycosisen_US
dc.subjectorbital exenterationen_US
dc.subjectdiabetes mellitusen_US
dc.subjectcorticosteroidsen_US
dc.titleDemographic and Clinical Profile of Patients Presenting with COVID-19-Associated Rhino-orbito-cerebral Mucormycosis at a Tertiary Care Centeren_US
dc.typeJournal Articleen_US
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