Evaluation of a single oral dose of diethylcarbamazine 300 mg as provocative test and simultaneous treatment in Myanmar migrant workers with Wuchereria bancrofti infection in Thailand.

Simple item page
dc.contributor.authorBhumiratana, Adisaken_US
dc.contributor.authorSiriaut, Chumsinen_US
dc.contributor.authorKoyadun, Suracharten_US
dc.contributor.authorSatitvipawee, Pratanaen_US
dc.date.accessioned2009-05-27T15:06:14Z
dc.date.available2009-05-27T15:06:14Z
dc.date.issued2004-09-04en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractWe assessed the efficiency of oral diethylcarbamazine (DEC) 300 mg as a provocative test on blood examination 30 minutes after administration, while gauging the overall infection rate in Myanmar migrant workers with Wuchereria bancrofti infection who enrolled for work permits in Thailand in 2002, using circulating filarial antigens (CFA) assays, the NOW ICT Filariasis card test and the Og4C3 ELISA as reference. Overall infection rates of 0.3% (95% CI=0-0.7%), 4.2% (95% CI=1.8-6.5%) and 5.9% (95% CI=3.2-8.7%) by three diagnostic tests, respectively, were observed. Among three different location groups of Myanmar population sample tested, there were no statistically significant differences in the overall infection detection rates. When either the ICT card test or the Og4C3 ELISA was used as a reference, the specificity and positive predictive value of the DEC-provocative day test was the same, 100%. The sensitivities were 25.0% (95% CI = 0.5-49.5%) and 17.6% (95% CI = 0-35.8%) on the ICT and ELISA tests, respectively. The negative predictive values were 96.8% (95% CI = 94.8-98.9%) and 95.1% (95% CI = 92.6-97.6%), respectively. In three microfilaremic persons followed-up monitored at 8-weeks DEC post-provocation, there were 6 x 10(-1) and 7 x 10(-1) decreases in microfilaremia and antigenemia. These findings suggested that, unlike the CFA assays, the DEC-provocative day test is unsuitable for the diagnosis of active W. bancrofti infection in the population tested, and for gauging current infection prevalence. The treatment would likely be beneficial to reduce microfilaremia and antigenemia.en_US
dc.description.affiliationDepartment of Parasitology, Faculty of Public Health, Mahidol University, Bangkok, Thailand. phabr@mahidol.ac.then_US
dc.identifier.citationBhumiratana A, Siriaut C, Koyadun S, Satitvipawee P. Evaluation of a single oral dose of diethylcarbamazine 300 mg as provocative test and simultaneous treatment in Myanmar migrant workers with Wuchereria bancrofti infection in Thailand. The Southeast Asian Journal of Tropical Medicine and Public Health. 2004 Sep; 35(3): 591-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/31922
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/2004_35_3/17-3304.pdfen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntigens, Helminth --blooden_US
dc.subject.meshDiethylcarbamazine --administration & dosageen_US
dc.subject.meshElephantiasis, Filarial --blooden_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshFemaleen_US
dc.subject.meshFilaricides --administration & dosageen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMass Screening --methodsen_US
dc.subject.meshMyanmar --ethnologyen_US
dc.subject.meshSensitivity and Specificityen_US
dc.subject.meshThailanden_US
dc.subject.meshTransients and Migrantsen_US
dc.subject.meshTreatment Outcomeen_US
dc.subject.meshWuchereria bancrofti --immunologyen_US
dc.titleEvaluation of a single oral dose of diethylcarbamazine 300 mg as provocative test and simultaneous treatment in Myanmar migrant workers with Wuchereria bancrofti infection in Thailand.en_US
dc.typeComparative Studyen_US
dc.typeEvaluation Studiesen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
591.pdf
Size:
57.13 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Southeast Asian Journal of Tropical Medicine and Public Health