Association between GSTM1 Gene Polymorphism and Oral Cavity Cancer in Suratthani Province

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dc.contributor.authorDanai Tiwawechen_US
dc.contributor.authorSomjin Chindavijaken_US
dc.contributor.authorSudjit Tongnunen_US
dc.contributor.authorTakafumi Ishidaen_US
dc.date.accessioned2011-02-22T08:15:49Z
dc.date.available2011-02-22T08:15:49Z
dc.date.created2010-04-07en_US
dc.date.issued2010-04-07en_US
dc.description.abstractOral cavity cancer (OCC) is a serious malignant disease in Thailand, particularly in the South, including Suratthani province, with a trend to increase in the number of its death yearly. However, patients with early stages of OCC are treatable. Hence, a mass screening for early stages of OCC patients without cancer-related symptoms is urgent. GSTM1 gene (GSTM1) that produced enzyme for detoxification of carcinogens has been reported to be polymorphic and associated with the risk of several cancer developments. The purpose of this study is to investigate the association between GSTM1 polymorphisms and the risk of OCC development in Suratthani province population. The frequency of GSTM1 genotypes [GSTM1 normal (GSTM1+) and GSTM1 null genotype (GSTM1-)] was detected in DNA extracted from peripheral white blood cells of 200 cases of OCC patients and 200 healthy controls using the polymerase chain reaction (PCR) assay. Overall, the frequency of GSTM1 genotypes between OCC and healthy control groups was significantly different (P \< 0.001). Individuals with GSTM1- had increased risk about 1.95-fold for OCC development as compared with those GSTM1+ [Odds ratio (OR) = 1.95, 95% confidence interval = 1.31-2.90]. In addition, GSTM1 polymorphism was found to be associated with an increased risk of OCC development in cigarette smokers, alcohol drinkers, and betel-nut chewers. In conclusion, the findings of this study suggest that GSTM1 polymorphism is associated with the risk of OCC development and the GSTM1- is the key factor for increasing the risk of OCC. Therefore, the detection of GSTM1 polymorphism is a useful tool in screening for the high-risk group that may be lead to identification of early stages of OCC in population who reside in Suratthani province.en_US
dc.identifier.citationThai Cancer Journal; Vol.29 No.3 July-September 2009; 115-125en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/132368
dc.language.isoen_USen_US
dc.publisherThai Cancer Journalen_US
dc.rightsNational Cancer Institute of Thailand, Bangkok, Thailanden_US
dc.source.urihttps://thailand.digitaljournals.org/index.php/TCJ/issue/archiveen_US
dc.source.urihttps://thailand.digitaljournals.org/index.php/TCJ/article/view/3071en_US
dc.titleAssociation between GSTM1 Gene Polymorphism and Oral Cavity Cancer in Suratthani Provinceen_US
dc.typeResearch Articlesen_US
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