Induction of oxidative stress in antitubercular drug-induced hepatotoxicity.

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dc.contributor.authorChowdhury, Aen_US
dc.contributor.authorSantra, Aen_US
dc.contributor.authorKundu, Sen_US
dc.contributor.authorMukherjee, Aen_US
dc.contributor.authorPandit, Aen_US
dc.contributor.authorChaudhuri, Sen_US
dc.contributor.authorDhali, G Ken_US
dc.date.accessioned2001-05-13en_US
dc.date.accessioned2009-05-29T03:30:04Z
dc.date.available2001-05-13en_US
dc.date.available2009-05-29T03:30:04Z
dc.date.issued2001-05-13en_US
dc.description.abstractBACKGROUND AND AIM: Oxidative stress could play a role in the pathogenesis of antitubercular drug (ATD)-induced hepatotoxicity. We therefore studied the plasma level of reduced glutathione (GSH) and malondialdehyde (MDA) in patients with ATD-induced hepatotoxicity (cases), ATD-treated controls (disease controls) and in healthy volunteers. METHODS: This study was carried out in a case-control design. Twenty-one cases, 21 age- and sex-matched disease controls, and 10 healthy volunteers were enrolled. Plasma levels of GSH and MDA were measured. RESULTS: Plasma levels of GSH (median [range] 11.5 [6.2-21.2] mmol/dL) and MDA (1390 [560-2310] nmol/dL) of cases were significantly different (p<0.01) from GSH (18.4 [10.5-24.4]) and MDA (290 [240-550]) of disease controls. Further, plasma GSH and MDA levels of both the ATD-treated groups were different from those in healthy controls. CONCLUSION: Lower levels of plasma GSH and higher levels of MDA may be due to oxidative stress resulting from ATD therapy.en_US
dc.description.affiliationDepartment of Gastroenterology, Institute of Post Graduate Medical Education and Research, Kolkata. achowdhury@apexmail.comen_US
dc.identifier.citationChowdhury A, Santra A, Kundu S, Mukherjee A, Pandit A, Chaudhuri S, Dhali GK. Induction of oxidative stress in antitubercular drug-induced hepatotoxicity. Indian Journal of Gastroenterology. 2001 May-Jun; 20(3): 97-100en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/65412
dc.language.isoengen_US
dc.source.urihttps://www.indianjgastro.comen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntitubercular Agents --adverse effectsen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlutathione --blooden_US
dc.subject.meshHepatitis, Toxic --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshLinear Modelsen_US
dc.subject.meshLiver Function Testsen_US
dc.subject.meshMaleen_US
dc.subject.meshMalondialdehyde --blooden_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshOxidative Stressen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshStatistics, Nonparametricen_US
dc.subject.meshTuberculosis --drug therapyen_US
dc.titleInduction of oxidative stress in antitubercular drug-induced hepatotoxicity.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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