Curcumin protects against failure to generate a transmembrane potential and protein aggregation of rat liver mitochondria induced by tert- butylhydroperoxides.

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dc.contributor.authorSuyatna, F D
dc.contributor.authorSusilowati, S
dc.contributor.authorSetiawati, A
dc.date.accessioned2013-10-29T08:34:34Z
dc.date.available2013-10-29T08:34:34Z
dc.date.issued2007-07
dc.description.abstractCurcumin, an active ingredient of curcuma plant has been thought to be beneficial in the treatment of liver diseases. In the previous studies, we have shown the protective effects of curcumin against lipid peroxidation and swelling of the rat liver mitochondrial preparation induced by tert-butylhydroperoxide (t-BuOOH). In the present study, the administration of t-BuOOH of 90 µM caused the mitochondria failed to generate a transmembrane potential (ψm). Of 3 doses of curcumin administered (0.5 µM, 2.5 µM dan 5.0 µM) the maximum protective effect against failure to generate a transmembrane potential caused by t-BuOOH was obtained by 2.5 µM of curcumin (79.13 + 6.28%). Further, curcumin of 1000 µM could prevent protein aggregation formation caused by t-BuOOH in the electrophoretogram. This study shows the protective effects of curcumin against damaged of energy production system and protein of the mitochondria caused by t-BuOOH.en_US
dc.identifier.citationSuyatna F D, Susilowati S, Setiawati A. Curcumin protects against failure to generate a transmembrane potential and protein aggregation of rat liver mitochondria induced by tert- butylhydroperoxides. Medical Journal of Indonesia. 2007 July; 16(3): 139-145.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/149065
dc.language.isoenen_US
dc.source.urihttps://mji.ui.ac.id/journal/index.php/mji/article/view/269en_US
dc.subjectcurcuminen_US
dc.subjectt-BuOOHen_US
dc.subjectmitochondriaen_US
dc.subjecttransmembrane potentialen_US
dc.subjectprotein electrophoresisen_US
dc.subject.meshCurcuminen_US
dc.subject.meshBlood Protein Electrophoresisen_US
dc.titleCurcumin protects against failure to generate a transmembrane potential and protein aggregation of rat liver mitochondria induced by tert- butylhydroperoxides.en_US
dc.typeArticleen_US
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