Hepatoid carcinoma of the gallbladder.

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dc.contributor.authorKoswara, Tejaen_US
dc.contributor.authorMarwoto, Wirasmien_US
dc.contributor.authorSiregar, Nurjati Cen_US
dc.contributor.authorGumay, Saukanien_US
dc.contributor.authorAzis, Husnien_US
dc.contributor.authorAbdullah, Murdanien_US
dc.contributor.authorHimawan, Sutisnaen_US
dc.date.accessioned2007-10-30en_US
dc.date.accessioned2009-05-28T04:31:20Z
dc.date.available2007-10-30en_US
dc.date.available2009-05-28T04:31:20Z
dc.date.issued2007-10-30en_US
dc.description.abstractHepatoid carcinoma is a special type of extrahepatic tumor associated with hepatic differentiation, and has the morphological and functional features of hepatocellular carcinoma. Hepatoid carcinoma of the gallbladder is very rarely reported in the literature. We report a case of hepatoid carcinoma of the gallbladder in a 71-year-old female who presented with abdominal pain and was first diagnosed as cholelithiasis with cholecystitis. The microscopic findings of the gallbladder after cholecystectomy showed an area of tumor with polygonal cells, eosinophilic cytoplasm, distinct cell borders, round vesicular nuclei and prominent nucleoli, arranged in trabecular pattern resembling hepatocellular carcinoma intermingled with areas of adenocarcinoma or cholangiocarcinoma. The specimen from the pancreas also showed the same type of tumor cells. Histochemically, some of tumor cells were positive for Victoria Blue, Stein, and PAS. The immunohistochemistry for alpha-fetoprotein (AFP) showed strong intra cytoplasmic positivity, both in tumor cells with hepatic differentiation and tumor cells with bile duct epithelium differentiation. Based on these findings, this case was diagnosed as hepatoid carcinoma of the gallbladder with metastasis to the pancreas. This is the first case that has been reported in our department.en_US
dc.description.affiliationDepartment of Anatomical Pathology, Faculty of Medicine, University of Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.en_US
dc.identifier.citationKoswara T, Marwoto W, Siregar NC, Gumay S, Azis H, Abdullah M, Himawan S. Hepatoid carcinoma of the gallbladder. Acta Medica Indonesiana. 2007 Oct-Dec; 39(4): 179-82en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/47008
dc.language.isoengen_US
dc.subject.meshAdenocarcinoma --secondaryen_US
dc.subject.meshAgeden_US
dc.subject.meshCarcinoma, Hepatocellular --diagnosisen_US
dc.subject.meshCholangiocarcinoma --secondaryen_US
dc.subject.meshCholecystectomyen_US
dc.subject.meshFatal Outcomeen_US
dc.subject.meshFatty Liver --pathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGallbladder Neoplasms --diagnosisen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshNecrosisen_US
dc.subject.meshPancreatic Neoplasms --diagnosisen_US
dc.subject.meshalpha-Fetoproteins --metabolismen_US
dc.titleHepatoid carcinoma of the gallbladder.en_US
dc.typeCase Reportsen_US
dc.typeJournal Articleen_US
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