Efficacy and safety of metformin immediate release versus extended release in drug naive patients with type 2 diabetes: A randomized controlled trial

Simple item page
dc.contributor.authorFarookh, SSen_US
dc.contributor.authorKamath, Len_US
dc.contributor.authorKR, R.en_US
dc.date.accessioned2025-05-14T09:32:53Z
dc.date.available2025-05-14T09:32:53Z
dc.date.issued2024-11
dc.description.abstractObjectives: This study aims to evaluate the efficacy and safety of metformin immediate release (IR) versus metformin extended release (ER) in patients with type 2 Diabetes. Materials and Methods: In this parallel-group, comparative, open-label clinical study, patients (n = 70) were as- signed to two groups: 35 patients were randomized to receive Metformin IR 500 mg tablet orally twice daily and the remaining 35 patients to receive Metformin ER 1000 mg tablet orally once daily for 12 weeks. Fasting plasma glucose (FPG), postprandial plasma glucose (PPG), and glycated hemoglobin (HbA1c) were recorded at the start and end of the study. Results: There was a significant decrease in FPG, PPG, and HbA1c glycemic parameters from baseline to week 12 in both Metformin IR and Metformin ER groups but the difference was not statistically significant between the groups. Incidence of adverse effects was less reported with the extended-release formulation. All patients tolerated both the formulations of metformin with good compliance. Conclusion: In this study, both Metformin IR and ER formulations demonstrated similar efficacy in improving gly- cemic control in drug naïve patients with type 2 diabetes. However, the ER formulation exhibited a superior safety profile, characterized by a reduced incidence of adverse effects, thereby improving drug compliance.en_US
dc.identifier.affiliationsDepartment of Pharmacology, Bangalore Medical College and Research Institute, Bengaluru, Indiaen_US
dc.identifier.affiliationsDepartment of Pharmacology, Bangalore Medical College and Research Institute, Bengaluru, Indiaen_US
dc.identifier.affiliationsDepartment of Medicine, Bangalore Medical College and Research Institute, Bengaluru, Indiaen_US
dc.identifier.citationFarookh SS, Kamath L, KR R.. Efficacy and safety of metformin immediate release versus extended release in drug naive patients with type 2 diabetes: A randomized controlled trial . National Journal of Physiology, Pharmacy and Pharmacology. 2024 Nov; 14(11): 2384-2390en_US
dc.identifier.issn2231-3206
dc.identifier.issn2320-4672
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/247851
dc.languageenen_US
dc.publisher?Eldaghayes Publisheren_US
dc.relation.issuenumber11en_US
dc.relation.volume14en_US
dc.source.urihttps://doi.org/10.5455/NJPPP.2024.v14.i11.8en_US
dc.subjectMetformin extended releaseen_US
dc.subjectMetformin immediate releaseen_US
dc.subjectGlycemic efficacyen_US
dc.subjectTolerabilityen_US
dc.subjectType 2 diabetesen_US
dc.titleEfficacy and safety of metformin immediate release versus extended release in drug naive patients with type 2 diabetes: A randomized controlled trialen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
njppp2024v14n11p2384.pdf
Size:
559.61 KB
Format:
Adobe Portable Document Format
Download
Collections
National Journal of Physiology, Pharmacy and Pharmacology