Evaluation of meibomian gland morphology and anterior segment parameters by Sirius topography systems in polycystic ovary syndrome

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dc.contributor.authorBal?kç?, Ay?e Tüfekçien_US
dc.contributor.authorUluta?, Hafize Gökbenen_US
dc.contributor.authorÖzgen, Gülten Aslanen_US
dc.date.accessioned2023-08-25T06:34:08Z
dc.date.available2023-08-25T06:34:08Z
dc.date.issued2022-08
dc.description.abstractPurpose: To compare findings in specular microscopy, corneal topography, and noncontact meibography in polycystic ovary syndrome (PCOS) patients with healthy controls. Methods: A total of 40 women with PCOS and 32 healthy controls were enrolled in the study. Schirmer’s test, Ocular Surface Disease Index (OSDI), noninvasive tear break-up time (NITBUT), the mean keratometry (Km), maximum keratometry (Kmax), central (CCT), thinnest (TCT) and apical (ACT) corneal thicknesses, meibomian gland (MG) loss, meiboscores, morphology of MGs, endothelial cell density (ECD), coefficient of variation (CV), and percentage of hexagonal cells (PHEX) were analyzed. Correlations between anti-Mullerian hormone (AMH) and sex hormones and the findings of PCOS patients were evaluated. Results: Mean OSDI score, intraocular pressure, Km and Kmax values, the mean MG loss of upper and lower eyelids, lower eyelid meiboscore, and degree of morphological abnormalities of MGs were higher in cases with PCOS than healthy controls. There were no significant differences between groups in Schirmer results, first and average NITBUT, mean values of TCT, ACT, CCT, ECD, CV, and PHEX (P > 0.05, for all). There were correlations between plasma AMH level and Kmax, back Km and PHEX, and between estradiol (E2) and PHEX; there were negative correlations between E2 and total MG loss and CV and between total testosterone and ACT. Conclusion: Loss and morphological deterioration of the MGs are observed in PCOS patients, even if the tear parameters are not impaired yet. In eyes with PCOS, keratometry values become steeper in proportion to AMH levels. The PCOS patients should be followed carefully for the development of corneal ectasia.en_US
dc.identifier.affiliationsDepartment of Ophthalmology, University of Health Sciences, Ankara Training and Research Hospital, Ankara, Turkeyen_US
dc.identifier.affiliationsDepartment of Ophthalmology, University of Health Sciences, Bursa Yüksek Ihtisas Training and Research Hospital, Bursa, Turkeyen_US
dc.identifier.affiliationsDepartment of Gynecology and Obstetrics, University of Health Sciences, Bursa Yüksek Ihtisas Training and Research Hospital, Bursa, Turkeyen_US
dc.identifier.citationBal?kç? Ay?e Tüfekçi, Uluta? Hafize Gökben, Özgen Gülten Aslan. Evaluation of meibomian gland morphology and anterior segment parameters by Sirius topography systems in polycystic ovary syndrome. Indian Journal of Ophthalmology. 2022 Aug; 70(8): 2922-2928en_US
dc.identifier.issn1998-3689
dc.identifier.issn0301-4738
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/224517
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber8en_US
dc.relation.volume70en_US
dc.source.urihttps://doi.org/10.4103/ijo.IJO_6_22en_US
dc.subjectCorneal topographyen_US
dc.subjectdry eyeen_US
dc.subjectkeratoconusen_US
dc.subjectnoncontact meibographyen_US
dc.subjectpolycystic ovary syndromeen_US
dc.subjectsex hormonesen_US
dc.subjectspecular microscopyen_US
dc.titleEvaluation of meibomian gland morphology and anterior segment parameters by Sirius topography systems in polycystic ovary syndromeen_US
dc.typeJournal Articleen_US
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