Umbilical cord mesenchymal stem cells in neurological disorders: A clinical study.

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dc.contributor.authorMiao, Xingyu
dc.contributor.authorWu, Xiaoying
dc.contributor.authorShi, Wei
dc.date.accessioned2015-06-23T07:46:25Z
dc.date.available2015-06-23T07:46:25Z
dc.date.issued2015-04
dc.description.abstractWe investigated the intrathecally administrated unbilical cord mesenchymal stem cells (UC-MSCs) by lumbar puncture and assessed the technical difficulties and effects in various neurological conditions. One hundred patients underwent subarachnoid placement of UC-MSCs between December 2006 and May 2010 in the Affiliated Hospital of Medicine. Technical difficulties in patients in the form of localization of subarachnoid space, number of attempts, and post-procedural complications were evaluated. Functional evaluation was done using Hauser Ambulation Index (HAI) by the stem cell transplant team on a regular basis. All patients were followed-up for more than 1 yr after the treatment. Clinical symptoms, related biochemical index and photographic examinations were observed regularly. We encountered technical difficulties in 31 patients (31%) in the form of general anesthesia supplementation and difficulty localizing the lumbar space. Side effects (headache, low-grade fever, low back pain and lower limb pain) were observed in 22 (22%) patients, which were treated with symptomatic therapy within 48 h. One year after the treatment, functional indices improved in 47 patients (47%): 12 patients with spinal cord injury, 11 patients with cerebral palsy, 9 patients with post-traumatic brain syndrome, 9 patients with post-brain infarction syndrome, 3 patients with spinocerebellar ataxias, and 3 patients with motor neuron disease. In conclusion,intrathecal administration of UC-MSCs is a safe and effective way to treat neurological disorders. Our encouraging results of intrathecal administration of UC-MSCs indicate the potential of restoration of lost tissue and improvement of function in patients with profound neurological defects and inefficient conventional cure. These data support expanded double-blind, placebo-controlled studies for this treatment modality.en_US
dc.identifier.citationMiao Xingyu, Wu Xiaoying, Shi Wei. Umbilical cord mesenchymal stem cells in neurological disorders: A clinical study.Indian Journal of Biochemistry & Biophysics. 2015 Apr; 52 (2): 140-146.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/158211
dc.language.isoenen_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/31524en_US
dc.subjectNeurological diseasesen_US
dc.subjectUmbilical cord mesenchymal stem cellsen_US
dc.subjectStem cellen_US
dc.subjectIntrathecal administrationen_US
dc.subjectLumbar punctureen_US
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshInjections, Spinal
dc.subject.meshMale
dc.subject.meshMesenchymal Stromal Cells
dc.subject.meshMiddle Aged
dc.subject.meshNervous System Diseases --therapy
dc.subject.meshStem Cells
dc.subject.meshUmbilical Cord --cytology
dc.subject.meshYoung Adult
dc.titleUmbilical cord mesenchymal stem cells in neurological disorders: A clinical study.en_US
dc.typeArticleen_US
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