A comparative study on the efficacy of albendazole and mebendazole in the treatment of ascariasis, hookworm infection and trichuriasis.

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dc.contributor.authorJongsuksuntigul, Pen_US
dc.contributor.authorJeradit, Cen_US
dc.contributor.authorPornpattanakul, Sen_US
dc.contributor.authorCharanasri, Uen_US
dc.date.accessioned2009-05-27T15:55:18Z
dc.date.available2009-05-27T15:55:18Z
dc.date.issued1993-12-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractA comparative study of the efficacy of albendazole and mebendazole was carried out in Pattani Province in the southern part of Thailand. One hundred and ninety-six patients with single or multiple infections with Ascaris, hookworm, and Trichuris were randomized into 4 groups for different treatments. Stool examination by Kato-Katz technique were done before and on day 14 after treatment. Results of the study showed that (1) a single dose of 300 mg mebendazole (locally produced) resulted in cure rates of 50%, 0% and 0% and egg reduction rates of 87.3%, -15.3%, and 28.3%, for ascariasis, hookworm infection and Trichuris respectively; (2) a single dose of 300 mg mebendazole (original) resulted in cure rates of 100.0%, 9.1%, and 43.3%, and egg reduction rates of 100.0%, 72.0%, and 77.9%, for Ascaris, hookworm, and Trichuris respectively; (3) a single dose 500 mg mebendazole (original) resulted in cure rates of 100.0%, 30.2%, and 70.3%, and egg reduction rates of 100.0%, 70.4% and 89.9%, for Ascaris, hookworm, and Trichuris respectively and (4) a single dose of 400 mg albendazole (original) resulted in cure rates of 100.0%, 84.3%, and 67.4%, and egg reduction rates of 100.0%, 96.0% and 87.0%, for Ascaris, hookworm, and Trichuris respectively. Both mebendazole and albendazole are safe and no side effects were observed. The results of this study suggested that albendazole is the preferred benzimidazole derivative for mass treatment of multiple infections with Ascaris, hookworm, and Trichuris.en_US
dc.description.affiliationDivision of General Communicable Diseases, Ministry of Public Health, Bangkok, Thailand.en_US
dc.identifier.citationJongsuksuntigul P, Jeradit C, Pornpattanakul S, Charanasri U. A comparative study on the efficacy of albendazole and mebendazole in the treatment of ascariasis, hookworm infection and trichuriasis. The Southeast Asian Journal of Tropical Medicine and Public Health. 1993 Dec; 24(4): 724-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/33986
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshAlbendazole --administration & dosageen_US
dc.subject.meshAscariasis --drug therapyen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshFeces --parasitologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHookworm Infections --drug therapyen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMebendazole --administration & dosageen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNematode Infections --drug therapyen_US
dc.subject.meshThailanden_US
dc.subject.meshTrichuriasis --drug therapyen_US
dc.titleA comparative study on the efficacy of albendazole and mebendazole in the treatment of ascariasis, hookworm infection and trichuriasis.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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