Granulocyte macrophage--colony stimulating factor (GM-CSF) as adjunct in induction therapy of acute myeloid leukemia.

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dc.contributor.authorGangadharan, V Pen_US
dc.contributor.authorPrakash, N Pen_US
dc.contributor.authorJayasree, Ken_US
dc.contributor.authorNayak, Nen_US
dc.date.accessioned2009-05-28T06:44:23Z
dc.date.available2009-05-28T06:44:23Z
dc.date.issued1999-03-16en_US
dc.description.abstractUse of growth factors (G-CSF/GM-CSF) as adjunct in induction therapy of AML is controversial. Possible stimulation of leukemia cell clones has been the major cause of concern. We treated 50 cases of AML with GM-CSF as an adjunct during induction therapy. 35 patients (70%) achieved complete remission out of which 13 patients relapsed at a median relapse period of 15 months. Average duration of neutropenia was 10.5 days. (15 days in the control) Febrile episodes were fewer and antibiotic support was required for an average period of only 7.6 days (16.9 days in the control). The benefits including the economic analysis of the role of GM-CSF in this setting is discussed.en_US
dc.description.affiliationDivision of Medical Oncology, Regional Cancer Centre, Thiruvananthapuram.en_US
dc.identifier.citationGangadharan VP, Prakash NP, Jayasree K, Nayak N. Granulocyte macrophage--colony stimulating factor (GM-CSF) as adjunct in induction therapy of acute myeloid leukemia. Indian Journal of Cancer. 1999 Mar; 36(1): 32-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/50305
dc.language.isoengen_US
dc.source.urihttps://www.indianjcancer.comen_US
dc.subject.meshAcute Diseaseen_US
dc.subject.meshAdjuvants, Immunologic --therapeutic useen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAnti-Bacterial Agents --therapeutic useen_US
dc.subject.meshAntibiotics, Antineoplastic --administration & dosageen_US
dc.subject.meshAntimetabolites, Antineoplastic --administration & dosageen_US
dc.subject.meshAntineoplastic Combined Chemotherapy Protocols --therapeutic useen_US
dc.subject.meshCytarabine --administration & dosageen_US
dc.subject.meshDaunorubicin --administration & dosageen_US
dc.subject.meshFemaleen_US
dc.subject.meshFever --prevention & controlen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshGranulocyte-Macrophage Colony-Stimulating Factor --therapeutic useen_US
dc.subject.meshHumansen_US
dc.subject.meshLeukemia, Myeloid --drug therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasm Recurrence, Localen_US
dc.subject.meshNeutropenia --etiologyen_US
dc.subject.meshRemission Inductionen_US
dc.titleGranulocyte macrophage--colony stimulating factor (GM-CSF) as adjunct in induction therapy of acute myeloid leukemia.en_US
dc.typeJournal Articleen_US
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